Results 161 to 170 of about 8,934 (195)

Familial TGCT: polygenic aetiology advanced

Nature Reviews Urology, 2018
A polygenic risk score (PRS) analysis reported that familial testicular germ cell tumours (TGCTs) were significantly enriched for TGCT risk alleles and that ≥84% were attributable to polygenic enrichment, supporting the polygenic aetiological basis of familial TGCT.
Ruth Pfeiffer
exaly   +3 more sources

The diffuse-type tenosynovial giant cell tumor (dt-TGCT) patient journey: a prospective multicenter study [PDF]

Orphanet Journal of Rare Diseases, 2021
Background: Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive neoplasm arising from the synovium of joints, bursae, and tendon sheaths affecting small and large joints.
Sebastian Bauer, Hans J. Gelderblom, Geert Spierenburg   +2 more
exaly   +2 more sources

Multimodal management of tenosynovial giant cell tumors (TGCT) in the landscape of new druggable targets

Journal of Surgical Oncology, 2023
AbstractTenosynovial giant cell tumor (TGCT) is a rare, benign, locally aggressive synovial based neoplastic process that can result in functional debilitation and end‐stage arthrtitis. Although surgical resection is the primary treatment modality, novel systemic therapies are emerging as part of the multimodal armamentarium for patients with ...
Geert Spierenburg, Nicholas M Bernthal
exaly   +3 more sources

Tenosynovial giant cell tumor (TGCT): Mechanisms and advances in targeted treatments

Critical Reviews in Oncology/Hematology
Tenosynovial giant cell tumors (TGCT) are rare, locally aggressive, mesenchymal tumors occurring in the joints and tendon sheaths, which can cause pain, swelling, and have a substantial negative impact on patient quality of life. While surgery is the current standard of care for most cases of TGCT, there are several drawbacks including risk of ...
Zhaoming Ye, Xiaohui Niu, Lin Nong
exaly   +3 more sources

Patient journey and quality of life (QOL) among diffuse-type TGCT in the U.S.

Journal of Clinical Oncology, 2020
e23565 Background: Diffuse Tenosynovial Giant Cell Tumor (d-TGCT) is a rare, locally aggressive neoplasm of joint and tendon sheath synovia, which may severely affect patients (pts) QOL due to pain, limited joint function and destruction of bone and local tissues.
Bernthal, Nicholas M., Spierenburg, Geert, van de Sande, Michiel, Healey, John H., Stacchiotti, Silvia, Bauer, Sebastian, Gelderblom, Hans, Staals, Eric, Lopez Bastida, Julio, Fronk, Eva-Maria, Ye, Xin, Laeis, Petra, Palmerini, Emanuela   +12 more
openaire   +1 more source

Testicular germ cell tumors (TGCTs) in neonates and infants

Seminars in Diagnostic Pathology, 2016
Dr. Louis Dehner has contributed significantly to our understanding of testicular germ cell tumors in children. This review article considers the molecular biology, clinical attributes, pathologic findings, and prognosis of those lesions.
openaire   +2 more sources

Evaluation of genes associated with undescended testes as predictors of TGCT susceptibility.

Journal of Clinical Oncology, 2012
1539 Background: Testicular germ cell tumors (TGCTs) are highly heritable. Cryptorchidism (undescended testes; UDT) is a strong risk factor for TGCT, with increased risk to both the ipsilateral and contralateral testes. However, recent genome-wide association studies (GWAS) identifying genetic variants associated with TGCT susceptibility have not ...
Ariela Marshall, Stephanie L. Ciosek, Saran Vardhanabhuti, Nandita Mitra, David J. Vaughn, Peter A. Kanetsky, Katharine Nathanson   +6 more
openaire   +1 more source

Emerging therapeutics in the management of tenosynovial giant cell tumor (TGCT)

Expert Review of Anticancer Therapy
Tenosynovial giant cell tumors (TGCTs) are locally aggressive mesenchymal neoplasms that often occur in younger patients and cause long-term disability. Surgical management remains the standard of care, but with high risks of surgical morbidity, systemic treatment options are important to consider, particularly in diffuse disease.
Victoria, Wytiaz, Geoffrey, Siegel, Rashmi, Chugh   +2 more
openaire   +2 more sources

Abstract 4669: Circulating cytokines as biomarkers of BEP toxicity in TGCTs patients

Cancer Research, 2017
Abstract Background: Cytokines are key components in process of inflammation and immune response, what are important processes in many toxicities. Bleomycin, etoposide, cisplatinum (BEP) is a standard treatment in patients with testicular germ cell tumors (TGCTs). Grade 3/4 toxicity can be dose limiting and can highly influence patient’s
Daniela Svetlovska, Viera Miskovska, Dana Cholujova, Paulina Gronesova, Silvia Cingelova, Michal Chovanec, Zuzana Sycova-Mila, Jana Obertova, Patrik Palacka, Vanda Usakova, Katarina Kalavska, Jan Luha, Dalibor Ondrus, Stanislav Spanik, Jozef Mardiak, Michal Mego   +15 more
openaire   +1 more source

Multifocality in testicular germ cell tumor (TGCT): what is the significance of this finding?

International Urology and Nephrology, 2013
The aim of the study is to determine the association between multifocality and the pathological features of testicular germ cell tumors and its clinical implication.Orchiectomy specimens from 254 consecutive patients with testis cancer between 2003 and 2013 were included. Multifocality was defined as a distinct tumor focus of cluster of malignant cells
Favilla V, RUSSO, GIORGIO IVAN, Spitaleri F, Urzì D, Garau M, Madonia M, Saita A, Pirozzi Farina F, LA VIGNERA, SANDRO SALVUCCIO MARIA, Condorelli R, CALOGERO, Aldo Eugenio, CIMINO, SEBASTIANO, MORGIA, Giuseppe Maria   +12 more
openaire   +3 more sources