Results 171 to 180 of about 8,934 (195)

Pexidartinib for advanced tenosynovial giant cell tumor (TGCT): Long-term efficacy and safety from the phase 3 ENLIVEN and phase 1 PLX108-01 (TGCT cohort) studies.

Journal of Clinical Oncology, 2019
11042 Background: TGCT is a rare, locally aggressive neoplasm of the joint/tendon sheath linked to colony-stimulating factor 1 (CSF1) overexpression. Pexidartinib (pex), a selective inhibitor of CSF1 receptor, KIT, and FLT3-ITD, had a compelling tumor response rate in the TGCT cohort of a phase 1 study (NCT01004861) and significant tumor response vs ...
Hans Gelderblom, William D. Tap, Emanuela Palmerini, Silvia Stacchiotti, Zev A. Wainberg, Jayesh Desai, John H. Healey, Michiel van de Sande, Nicholas M. Bernthal, Charles Peterfy, Dale Edward Shuster, Qiang Wang, Henry Hsu, Andrew J. Wagner   +13 more
openaire   +1 more source

Transcriptomic analysis of TGCT

Nature Reviews Urology, 2022
openaire   +2 more sources

Analysis of protein expression - possible panel for TGCT diagnostics

2019
Testicular germ cell tumor (TGCT) represents only 1% of all malignancies. However, it affects the young male population, thereby decreasing the quality of their reproductive health. TGCT is divided into seminomas(SE) and nonseminomas(NS). The Iatter group consists of four histologically different types, i.e.
Raos, Dora, Krasić, Jure, Mašić, Silvija, Čorić, Marijana, Krušlin, Božo, Katušić Bojanac, Ana, Bulić- Jakuš, Floriana, Ježek, Davor, Ulamec, Monika, Sinčić, Nino   +9 more
openaire   +2 more sources

TENOSYNOVIAL GIANT CELL TUMOR (TGCT) OF HIP- A RARE CASE REPORT

INDIAN JOURNAL OF APPLIED RESEARCH
Tenosynovial giant cell tumor (TGCT) is a relatively rare inammatory disease that affects the joint synovium, bursae, and tendon sheaths, leading to nonspecic, often insidious discomfort in the joints. Surgery, with or without adjuvant radiation, is the primary therapy option for tenosynovial giant cell tumor.
Ambareesh P, Supreeth D R, Nishanth Reddy J, Vishwanath M S, Varun GBS, Shashank Sonth, Harish DV, Chandan Kumar RV, Nabhay G, Mahadeva HN   +9 more
openaire   +1 more source

Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)

Bioorganic and Medicinal Chemistry Letters, 2022
Michael D Kaufman, Bryan D Smith
exaly  

One-Stage Synovectomies Result in Improved Short-Term Outcomes Compared to Two-Stage Synovectomies of Diffuse-Type Tenosynovial Giant Cell Tumor (D-TGCT) of the Knee: A Multicenter, Retrospective, Cohort Study

Cancers, 2023
Hans J. Gelderblom, Geert Spierenburg, R Lor Randall   +2 more
exaly  

No major predisposition gene in TGCT

Nature Reviews Urology, 2018
openaire   +1 more source

Bilateral testicular germ cell tumors (TGCT)

European Journal of Cancer, 1997
A. Gerl, M. Hentrich, C. Clemm, R. Hartenstein, T. Schuster, W. Wilmanns   +5 more
openaire   +1 more source

Establishment and characterization of a novel cell line, NCC-TGCT1-C1, derived from a patient with tenosynovial giant cell tumor

Human Cell, 2020
Tadashi Kondo, Kazutaka Kikuta, Rei Noguchi   +2 more
exaly  

Proximity to endocrine-disrupting pesticides and risk of testicular germ cell tumors (TGCT) among adolescents: A population-based case-control study in California

International Journal of Hygiene and Environmental Health, 2022
Robert Gunier, Xiaomei Ma, Libby M Morimoto   +2 more
exaly