Results 201 to 210 of about 138,672 (332)

RBFOX1 Dysfunction Unlocks APOE4‐Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids

Exploration, EarlyView.
Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9‐mediated RBFOX1 loss in APOE4 human cerebral organoids induces autonomous microglial genesis and accelerates AD pathology, revealing a protective role of RBFOX1 and establishing a model ...
Bowen Zhang, Changjie Shi, Jiayi Zhao, Qiuhong Hua, Houchun Zhang, Hailin Gao, Yuanyuan Qian, Jiaxue Cha, Jing Li, Jiayao Chen, Tae‐Hyung Kim, Jianhuang Xue, Yujun Hou, Ru Zhang   +13 more
wiley   +1 more source

Supplemental Figure Legends from Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition

, 2023
Lin Xiao, Dae Joong Kim, Clayton Davis, James V. McCann, James M. Dunleavey, Alissa K. Vanderlinden, Nuo Xu, Samantha G. Pattenden, Stephen V. Frye, Xia Xu, Mark W. Onaitis, Elizabeth Monaghan-Benson, Keith Burridge, Andrew C. Dudley   +13 more
openalex   +1 more source

Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration [PDF]

, 2023
Yuting Niu, Zhen Yang, Yang Yang, Xu Wang, Ping Zhang, Longwei Lv, Sainan Wang, Yan Liu, Yunsong Liu, Yongsheng Zhou   +9 more
openalex   +1 more source

Chloride Intracellular Channel 2 Can Function as a Malignant Factor in Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background The association of chloride intracellular channel 2 (CLIC2) with tumors has remained unclear. However, recently, CLIC2 was found to exhibit antitumor properties in some tumors. In this study, we aimed to evaluate the clinical relevance of CLIC2 expression in head and neck squamous cell carcinoma (HNSCC) to determine whether it ...
Yuki Hosokawa, Shoko Miyoshi, Yuji Hayashi, Yuki Irifune, Eriko Sato, Sohei Mitani, Mohammed Choudhury, Hajime Yano, Junya Tanaka, Naohito Hato   +9 more
wiley   +1 more source

Supplementary Materials and Methods from Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling

, 2023
Mariana Terra, Marine Oberkampf, Catherine Fayolle, Pierre Rosenbaum, Camille Guillerey, Gilles Dadaglio, Claude Leclerc   +6 more
openalex   +1 more source

The roles of TGFβ and serotonin signaling in regulating proliferation of oocyte precursors and germline aging [PDF]

Erin Z. Aprison, Svetlana Dzitoyeva, Ilya Ruvinsky   +2 more
openalex   +1 more source

Data from Human ESC Self-renewal Promoting microRNAs Induce Epithelial–Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways

, 2023
Christine Jung, Sushma Iyengar, Kimberly R. Blahnik, Joy X. Jiang, Candice Tahimic, Natalie J. Török, Ralph W. de Vere White, Peggy Farnham, Mark Α. Zern   +8 more
openalex   +1 more source

Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner [PDF]

, 2023
Carole Y. Perrot, Τheodoros Karampitsakos, Avraham Unterman, Taylor Adams, K. Marlin, Alyssa Arsenault, Amy Zhao, Naftali Kaminski, Gundars Katlaps, K. Patel, Debabrata Bandyopadhyay, Jose D. Herazo‐Maya   +11 more
openalex   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Data from USP11 Enhances TGFβ-Induced Epithelial–Mesenchymal Plasticity and Human Breast Cancer Metastasis

, 2023
Daniel Garcia, Christina Baek, Mónica V. Estrada, Tiffani Tysl, Eric J. Bennett, Jing Yang, John T. Chang   +6 more
openalex   +1 more source