Results 211 to 220 of about 138,672 (332)

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Data from TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent

, 2023
Erik Hedrick, Kumaravel Mohankumar, Stephen Safe   +2 more
openalex   +1 more source

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, EarlyView.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source

Splicing Isoforms Associated with TGFβ-Induced Myofibroblast Activation [PDF]

Opeoluwa Alli-Oke, Danny Bergeron, Fiona Kessai, Philippe Thibault, Mathieu Durand, Jean‐Philippe Brosseau   +5 more
openalex   +1 more source

Human cord blood (CB) derived unrestricted somatic stem cells (USSCs) suppress TGFβ signaling in recessive dystrophic epidermal lysis bullosa (RDEB) [PDF]

Cytotherapy, 2017
Yanling Liao, Larisa Ivanova, Trevor Plumer, Annie Gevertz, Brinda Mehta, Mitchell S. Cairo   +5 more
openaire   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer. [PDF]

Sci Adv
Parikainen M, Suwal U, Rappu P, Heino J, Sahlgren CM.   +4 more
europepmc   +1 more source

549 Phase 2 trial of TU2218, TGFβ-RI and VEGF-R2 dual inhibitor in combination with pembrolizumab in patients with head and neck squamous cell carcinoma [PDF]

Sungbae Kim, Bhumsuk Keam, Chang Gon Kim, Jin Won Kim, Jin Hyoung Kang, Ho‐Jung An, Jihyun Park, Hun-Taek Kim, Marya Chaney   +8 more
openalex   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

FAK Is Required for TGFβ-induced JNK Phosphorylation in Fibroblasts: Implications for Acquisition of a Matrix-remodeling Phenotype

, 2007
Shangxi Liu, Shiwen Xu, Laura Kennedy, Daphne Pala, Yunliang Chen, Mark Eastwood, David E. Carter, Carol M. Black, David Abraham, Andrew Leask   +9 more
openalex   +2 more sources