Results 231 to 240 of about 418,971 (241)

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

MMP14-Dependent Activation of TGF-β Signaling Enhances Malignancies via Promoting Necroptosis in Glioblastoma. [PDF]

FASEB J
Zhou H, Wu W, Cao Y, Zhang B, Zhou M, Wang Y, Wang M, Wang J.   +7 more
europepmc   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Disrupting the TGF-β-regulated epithelial-mesenchymal transition, apoptotic and autophagic phenotypes of 3D glioblastoma spheroids via glycolytic inhibition. [PDF]

Explor Target Antitumor Ther
Payet-Desruisseaux M, Zgheib A, Danalache BA, Desjarlais M, Annabi B.   +4 more
europepmc   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Double, double toil and trouble: transforming growth factor beta (TGF-β) in HIV infection. [PDF]

Front Immunol
Harrison-Gleason J, Yerlioglu KL, Halle AW, Hultquist JF, Martinelli E.   +4 more
europepmc   +1 more source

Antifibrotic Effect of the TGF-β Type I Receptor Inhibitor EW-7197 on Anastomotic Healing in a Rat Choledochojejunostomy Model. [PDF]

Biomedicines
Aslan F, Binici S, Eryılmaz I, Beger B, Beger O, İliklerden ÜH, Özalp İ, İlik ZA, Karakoyun F, Şahinalp Ş, Öner MÖ, Kotan MÇ.   +11 more
europepmc   +1 more source

The role of TGF-β superfamily in endometriosis: a systematic review. [PDF]

Front Immunol
Xu X, Li J, Lin H, Lin Z, Ji G.
europepmc   +1 more source

Structural and functional analysis of the TGF-β mimic, TGM-2: an immunomodulatory helminth protein. [PDF]

Genes Immun
Ntang EY, Cunningham KT, Singh SP, Ciancia C, Sanders A, Lilla S, Mukundan A, Ghogomu SM, Hinck AP, Maizels RM.   +9 more
europepmc   +1 more source

Beyond VEGF and TGF-β: A Comprehensive Review of Growth Factor Pathways in the Pathophysiology of Uterine Leiomyomas. [PDF]

Biology (Basel)
Rozmurat N, Terzic S, Zhao P, Bapayeva G, Kongrtay K, Tanko MN, Terzic M.   +6 more
europepmc   +1 more source