Results 231 to 240 of about 431,292 (339)

Effects of dopamine (DA) on mRNA and protein expression of factors in the YAP-TGF-β-Smad signaling pathway in ARPE-19 cells.

Jing Fan (149601), Qiujin Zhang (472724), Liu Zheng (1880860), Binbin Yang (2259313), He Jin (12261804), Tingyu Meng (22560141), Zhixiang Ding (15349443)   +6 more
openalex   +1 more source

RGS3 functions as a tumor promoter by facilitating the activation of the TGF-β signaling pathway and promoting EMT in ovarian cancer. [PDF]

Jinhua Zhou, Zizhao Wang, Huating Sun, Shunpeng Zhu, Fang Wang, Quan Li   +5 more
openalex   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Control of airway basal stem cell-mediated lung repair by TGF-β signaling. [PDF]

Sci Adv
Zou T, Zhang S, Liu M, Chen Q, Wang S, Niu L, Chen YG, Zhang T, Zuo W.   +8 more
europepmc   +1 more source

Review for "Tubular dentin formation by TGF‐β/BMP signaling in dental epithelial cells"

, 2021
Hidemitsu Harada
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Platelet Secretome Drives Mitogenic and TGF-β Responses in Gingival Fibroblasts. [PDF]

Biology (Basel)
Panahipour L, Riberti M, Huang X, Fischer MB, Miron RJ, Gruber R.   +5 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

LAMC2 promotes gallbladder carcinoma metastasis through the TGF-β pathway. [PDF]

Cancer Cell Int
Xu M, Zhang Y, Feng H, Shang T, Chen Y, Liu E, Lin Y, Pan Y, Zhou Y, Feng X, Dong L, Jiang T, Wang H.   +12 more
europepmc   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source