Results 241 to 250 of about 2,112,620 (360)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

TNF-α induces TGF-β₁expression in lung fibroblasts at the transcriptional levelviaAP-1 activation [PDF]

Journal of Cellular and Molecular Medicine, 2009
Deborah E. Sullivan, MaryBeth Ferris, Hong Nguyen, Elizabeth Abboud, Arnold R. Brody   +4 more
openaire   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size. [PDF]

Nat Immunol
Ghneim K, Ten-Caten F, Santana AC, Latif MB, Diaz-Dinamarca DA, García-Salum T, Del Rio Estrada PM, Sohal P, Strongin Z, Harper J, Jean S, Wallace C, Balderas R, Lifson JD, Raghunathan G, Rimmer E, Pastuskovas CV, Wu G, Micci L, Martins Sieben LF, Lopes Gerum PC, Dos Santos J, Netea MG, van der Ven A, Silvestri G, Hazuda DJ, Gorman DM, Howell BJ, Sharma AA, Paiardini M, Soudeyns H, Pereira Ribeiro S, Sekaly RP.   +32 more
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Non-Smad Signaling Pathways of the TGF-β Family.

Cold Spring Harbor Perspectives in Biology, 2017
Ying E. Zhang
semanticscholar   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Erratum: IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma. [PDF]

iScience
Zhang X, Wang G, Gong Y, Zhao L, Song P, Zhang H, Zhang Y, Ju H, Wang X, Wang B, Ren H, Zhu X, Dong Y.   +12 more
europepmc   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis. [PDF]

Bone Res
Choi A, Lee JY, Yoon H, Che X, Choi M, Park Y, Shin K, Lee H, Park J, Kong SH, Kim J, Lee AC, Shin CS, Choi JY, Lee J, Kwon S, Kim SW.   +16 more
europepmc   +1 more source