Results 261 to 270 of about 320,405 (317)

Resolvin D1 attenuates senescence-associated secretory phenotype independently of TGF-β-driven cardiac fibroblasts differentiation to myofibroblast. [PDF]

J Inflamm (Lond)
Román M, Osorio JM, Espinoza-Pérez C, Machuca V, Peiró C, Ferrer CS, Vivar R, Díaz-Araya G.   +7 more
europepmc   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Control of airway basal stem cell-mediated lung repair by TGF-β signaling. [PDF]

Sci Adv
Zou T, Zhang S, Liu M, Chen Q, Wang S, Niu L, Chen YG, Zhang T, Zuo W.   +8 more
europepmc   +1 more source

298 Therapeutic potential of IMPT-601, a Claudin18.2/TGF-β bispecific CAR, against gastric cancer

Melanie L. Munguia, Jessica Reyes, Orit Foord, Ethan BenDavid, Jiajia Cui   +4 more
openalex   +1 more source

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

Recent advances in nanoparticles targeting TGF-β signaling for cancer treatment. [PDF]

Theranostics
Li Z, Ji X, Cong X, Gao Y, Gao J.
europepmc   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β. [PDF]

Circ Res
Sakkers TR, Mili E, Winter H, Kapteijn D, Perry RN, Barbera N, Watts K, Dias IR, Meteva D, Wesseling M, Mol BM, de Borst GJ, de Kleijn DPV, van der Laan SW, Civelek M, White SJ, Maegdefessel L, Mayr M, Pasterkamp G, Mokry M, Benavente ED, den Ruijter HM.   +21 more
europepmc   +1 more source

TNF receptor-associated factor 6 (TRAF6) mediates the angiotensin-induced non-canonical TGF-β pathway activation of c-kit(+) cardiac stem cells.

, 2015
Qing Cao, Yuqiang Wang, Liya Huang, Fei Wang, Shuyan Chen   +4 more
openalex   +1 more source