Results 251 to 260 of about 320,405 (317)

Identification and characterization of a TGF-β-independent SMAD4-NFATc1-STAT3 regulatory axis. [PDF]

J Mol Cell Biol
Ouyang W, Hao J, Niu Q, Douglass EF, Beusch CM, Gordon DE, Hall M, Moffitt RA, Du Y, Mo X.   +9 more
europepmc   +1 more source

Lysine acetyltransferase 14 mediates TGF-β-induced fibrosis in ovarian endometrioma via co-operation with serum response factor

Yi Gong, Mian Liu, Qianqian Zhang, Jinjing Li, Hong Cai, Ran Jing, Linna Ma, Yanlin Ma, Song Quan   +8 more
openalex   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size. [PDF]

Nat Immunol
Ghneim K, Ten-Caten F, Santana AC, Latif MB, Diaz-Dinamarca DA, García-Salum T, Del Rio Estrada PM, Sohal P, Strongin Z, Harper J, Jean S, Wallace C, Balderas R, Lifson JD, Raghunathan G, Rimmer E, Pastuskovas CV, Wu G, Micci L, Martins Sieben LF, Lopes Gerum PC, Dos Santos J, Netea MG, van der Ven A, Silvestri G, Hazuda DJ, Gorman DM, Howell BJ, Sharma AA, Paiardini M, Soudeyns H, Pereira Ribeiro S, Sekaly RP.   +32 more
europepmc   +1 more source

Bioflavonoid combination attenuates diabetes-induced nephropathy in rats via modulation of MMP-9/TIMP-1, TGF-β, and GLUT-4-associated pathways

Ritu, Yifan Xiong, Hanuman Prasad Sharma, Ramesh K. Goyal, Sonia Narwal, Ajay Berwal, Sourabh Jain, M Nissi Priya, Manisha Singh, Gaurav Agarwal, Xiaoyan Wang, Bairong Shen, Rajeev K. Singla   +12 more
openalex   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Interplay between microRNAs and TGF-β signaling in T cells: implications for Th9 differentiation and immune pathogenesis. [PDF]

Front Immunol
Kim TS, Lim YJ, Chen W.
europepmc   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis. [PDF]

Bone Res
Choi A, Lee JY, Yoon H, Che X, Choi M, Park Y, Shin K, Lee H, Park J, Kong SH, Kim J, Lee AC, Shin CS, Choi JY, Lee J, Kwon S, Kim SW.   +16 more
europepmc   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source