Results 281 to 290 of about 2,112,620 (360)

TGF-β-driven NK Cells plasticity in hepatocellular carcinoma. [PDF]

Front Immunol
Reverberi V, Montali A, Vecchi A, Rossi M, Pelagatti A, Doselli S, Farina B, Olivani A, Economopoulos G, Dalla Valle R, Laccabue D, Ferraglia F, Penna A, Fisicaro P, Boni C, Missale G.   +15 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF-β/Smad3 Signaling. [PDF]

Adv Sci (Weinh)
Li J, Wu C, Zhu Y, Liu Z, Yu W, Lukwaro A, Zhong Y, Xie G, Zhou L, Huang X, Lan HY, Chen J, Tang Y.   +12 more
europepmc   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Single-cell capture of on-ART SIV transcription reveals TGF-β-mediated metabolic control of viral latency. [PDF]

JCI Insight
Abd-El-Raouf R, Harrison-Gleason J, Kim J, Wai CM, Yerlioglu KL, Ananias-Saez C, Ksiazek A, Poomkudy JT, Araínga M, Bose D, Cicala C, Arthos J, Villinger FJ, Lorenzo-Redondo R, Martinelli E.   +14 more
europepmc   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Liver sinusoidal endothelial TGF-β signaling accelerates partial endothelial-mesenchymal transition and MASH through Notch. [PDF]

JHEP Rep
Yang Z, Li QT, Yue ZS, Li ZW, Zou P, Ling YW, Xu H, Xu M, He F, Duan JL, Wang L.   +10 more
europepmc   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Polyplex of peptide-mannan and RNA for intranasal delivery of TGF-β siRNA in treatment of pulmonary fibrosis. [PDF]

Bioact Mater
Feng B, Singh A, Yang Y, Phan P, Xu H, Zhu Y, Huang J, Sastry V, Zhao Z, Hu YS, Cheng G, Malik AB, Liu Y.   +12 more
europepmc   +1 more source