Results 291 to 300 of about 431,292 (339)

Losartan attenuates depression-like behavior in epileptic rats by regulating the TGF-β/Smad signaling. [PDF]

IBRO Neurosci Rep
Cao P, Shen S, Fang Z, Tan J, Wang J, Pan N.   +5 more
europepmc   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Serum Proteomic Profile Based on the TGF-β Pathway Stratifies Risk of Hepatocellular Carcinoma. [PDF]

Liver Int
Xiang X, Shetty K, Yu H, Mishra B, Wong LL, Zhou XJ, Satapathy SK, Crawford JM, Latham PS, Han SH, Mathew B, Dagher NN, Lau L, Cacaj F, Vegesna AK, Dasarathy S, He AR, Huang H, Amdur RL, Mishra L.   +19 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway. [PDF]

Int J Mol Sci
Zeng Q, Liao ML, Luo YY, Li S, You G, Huang CM, Liu MH, Liu W, Tang SY.   +8 more
europepmc   +1 more source

Losartan alleviated synovitis in patients with metabolic osteoarthritis by down-regulating AT1R to inhibit TGF-β signaling. [PDF]

J Orthop Surg Res
Zhang H, Zhu J, He H, Li B, Wang H, Chen L, Ni Q.   +6 more
europepmc   +1 more source

TGF-β Signaling and miRNAs Targeting for BMP7 in the Spleen of Two Necrotic Enteritis-Afflicted Chicken Lines

, 2017
Anh Duc Truong, Yeojin Hong, Janggeun Lee, Kyungbaek Lee, Hyun S. Lillehoj, Yeong Ho Hong   +5 more
openalex   +2 more sources

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. [PDF]

Circulation
Tuleta I, Venugopal H, O'Leary K, Zheng D, Frangogiannis NG.   +4 more
europepmc   +1 more source

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

, 2014
Nathalie Schmitt, Yang Liu, Salah-Eddine Bentebibel, Indira Munagala, Laure Bourdery, K. Venuprasad, Jacques Banchereau, Hideki Ueno   +7 more
openalex   +1 more source