Replicator Dynamics of of Cancer Stem Cell; Selection in the Presence of Differentiation and Plasticity [PDF]
arXiv, 2014 Stem cells have the potential to produce lineages of non-stem cell populations (differentiated cells) via a ubiquitous hierarchal division scheme. Differentiation of a stem cell into (partially) differentiated cells can happen either symmetrically or asymmetrically. The selection dynamics of a mutant cancer stem cell should be investigated in the light
arxiv
Nature Communications, 2017 We have previously reported the molecular signature of murine pathogenic TH17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals.
Dan Hu +19 more
semanticscholar +1 more source
Cellular Physiology and Biochemistry, 2014 Background: CD4+CD25+ regulatory T (Treg) cells and T-helper 17 (Th17) cells play important roles in acute cerebral infarction (ACI). Our previous findings have suggested that oxidized low-density lipoprotein (Ox-LDL) could influence Treg/Th17 ratio in ...
Qing Li +4 more
doaj +1 more source
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. [PDF]
, 2012 Emerging evidence suggests that the T helper 17 (T(H)17) subset of αβ T cells contributes to the development of allergic asthma. In this study, we found that mice lacking the αvβ8 integrin on dendritic cells did not generate T(H)17 cells in the lung and ...
Atabai, Kamran +11 more
core +1 more source
Th17 cell induction and immune regulatory effects [PDF]
, 2007 Yujing Bi, Guangwei Liu, Ruifu Yang
openalex +1 more source
Immunomodulatory effect of Ganoderma atrum polysaccharides on Th17/Treg balance
Journal of Functional Foods, 2018 Th17 and regulatory T (Treg) cells are two new subsets of T cells. An increasing number of evidences suggest that Th17/Treg balance plays a vital role in maintenance of immune homeostasis. The present study aims to investigate the immunomodulatory effect
Quandan Xiang +6 more
doaj
T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation [PDF]
, 2007 Ming O. Li +2 more
openalex +1 more source
CD28-Dependent CTLA-4 Expression Fine-Tunes the Activation of Human Th17 Cells
iScience, 2020 Summary: Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells. We
Scott M. Krummey +3 more
doaj
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells [PDF]
, 2007 Heather Kopf +3 more
openalex +1 more source
Cutting Edge: CNS CD11c+ Cells from Mice with Encephalomyelitis Polarize Th17 cells and Support CD25+CD4+ T cell-Mediated Immunosuppression, Suggesting Dual Roles in the Disease Process [PDF]
, 2007 Pratima Deshpande +2 more
openalex +1 more source