Results 181 to 190 of about 10,836,682 (383)

FRI0187 PRELIMINARY EXPLORATION OF NEW METHODS TREAT TO PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: REGULATING TH17/TREG CELL BALANCE BY RAPAMICIN AND ALL-TRANS RETINOIC ACID [PDF]

, 2019
Yanfang Chu, Chunmiao Zhao, Bingying Zhang, Xuxia Wang, Yiqi Wang, Jia An, Junwei Chen, Xiaofeng Li   +7 more
openalex   +1 more source

SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation [PDF]

, 2021
Yi Tian, Chao Han, Zhiyuan Wei, Hui Dong, Xiaohe Shen, Yiqiang Cui, Xiaolan Fu, Zhiqiang Tian, Shufeng Wang, Jian Zhou, Di Yang, Yi Sun, Jizhao Yuan, Bing Ni, Yuzhang Wu   +14 more
openalex   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. [PDF]

, 2019
T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute to the pathogenesis of multiple autoimmune diseases and have been targeted therapeutically.
Anderson, Mark S, Cortez, Jessica T, Eckalbar, Walter L, Erle, David J, Sin, Jun Hyung, Waterfield, Michael R, Zuckerman, Cassandra   +6 more
core  

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Transcriptional features of Th2 and Th17-priming dendritic cells [PDF]

, 2018
Miranda L. Curtiss, Travis Ptacek, Alexander F. Rosenberg, Christopher D. Scharer, Daniel J. Silberger, Casey T. Weaver, Frances E. Lund   +6 more
openalex   +1 more source

Th17 cell

Citation: 'Th17 cell' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13722 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Cell, 2009
I. Ivanov, K. Atarashi, N. Manel, Eoin L. Brodie, T. Shima, U. Karaoz, D. Wei, Katherine C. Goldfarb, C. Santee, S. Lynch, Takeshi Tanoue, A. Imaoka, K. Itoh, K. Takeda, Y. Umesaki, K. Honda, D. Littman   +16 more
semanticscholar   +1 more source