Results 11 to 20 of about 4,870,412 (256)

Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance

Haematologica, 2012
Background The levels and clinical relevance of Th17 cells and other interleukin-17-producing cells have not been analyzed in chronic lymphocytic leukemia.
Preetesh Jain, Mohammad Javdan, Franziska K. Feger, Pui Yan Chiu, Cristina Sison, Rajendra N. Damle, Tawfiqul A. Bhuiya, Filiz Sen, Lynne V. Abruzzo, Jan A. Burger, Andreas Rosenwald, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Nicholas Chiorazzi, Barbara Sherry   +15 more
doaj   +2 more sources

Identification of Th1-polarized Th17 cells: solving the problem [PDF]

Медицинская иммунология, 2023
Helper T cells producing IL-17 (Th17) have high plasticity: restimulation of lymphocytes in an inflammatory environment can induce their transformation into cells with another phenotype, and a shift towards Th1 is the most common.
E. M. Kuklina, N. S. Glebezdina
doaj   +2 more sources

Inflammatory Th17 Cells Express Integrin αvβ3 for Pathogenic Function [PDF]

Cell Reports, 2016
Interleukin-23 (IL-23) is required for inflammatory Th17 cell function in experimental autoimmune encephalomyelitis (EAE), and IL-23 blockade reduces the number of effector Th17 cells in the CNS.
Fang Du, Abhishek V. Garg, Karis Kosar, Saikat Majumder, David G. Kugler, Gerard Hernandez Mir, Maria Maggio, Matthew Henkel, Adam Lacy-Hulbert, Mandy J. McGeachy   +9 more
doaj   +2 more sources

Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration

Cell Reports, 2021
Summary: Pathogenic Th17 cells drive inflammation in autoimmune disease, yet the molecular programming underlying Th17 cell pathogenicity remains insufficiently understood.
Kathryne E. Marks, Stephanie Flaherty, Kristen M. Patterson, Matthew Stratton, Gustavo J. Martinez, Joseph M. Reynolds   +5 more
doaj   +1 more source

CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease

Frontiers in Aging Neuroscience, 2023
BackgroundParkinson’s disease (PD), which is associated to autoimmune disorders, is characterized by the pathological deposition of alpha-synuclein (α-Syn) and loss of dopaminergic (DA) neurons.
Jingwei Zhao, Ke An, Zhijuan Mao, Yi Qu, Danlei Wang, Jiangting Li, Zhe Min, Zheng Xue   +7 more
doaj   +1 more source

Ursolic acid inhibits Th17 cell differentiation via STAT3/RORγt pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression

Innate Immunity, 2022
Th17 cells represent important immune cells. Ursolic acid (UA) can regulate immune cell activities. This study was aimed to explore the effects of UA on Th17 cell differentiation and Schwann cell(SCs)-mediated migration and the potential mechanism. Naïve
Hua Xu, Ai-ling Yu, Da-peng Zhao, Guang-yuan Meng, Ling Wang, Min Shan, Nai-xia Hu, Yun-lin Liu   +7 more
doaj   +1 more source

Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.

PLoS Pathogens, 2022
Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a major health burden worldwide. CD4+ T helper cells are involved in the immune response to S. aureus by supporting antibody production and phagocytosis.
Patricia Bartsch, Christoph Kilian, Malte Hellmig, Hans-Joachim Paust, Alina Borchers, Amirrtavarshni Sivayoganathan, Leon Enk, Yu Zhao, Nikhat Shaikh, Henning Büttner, Milagros N Wong, Victor G Puelles, Thorsten Wiech, Richard Flavell, Tobias B Huber, Jan-Eric Turner, Stefan Bonn, Samuel Huber, Nicola Gagliani, Hans-Willi Mittrücker, Holger Rohde, Ulf Panzer, Christian F Krebs   +22 more
doaj   +1 more source

Increased Proportion of Dual-Positive Th2–Th17 Cells Promotes a More Severe Subtype of Asthma

Canadian Respiratory Journal, 2021
Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma’s pathophysiological changes. Dual-positive Th2–Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce
Wenjin Sun, Yu Yuan, Lulu Qiu, Qingping Zeng, Jingsi Jia, Xudong Xiang, Aijun Jia, Libing Ma, Shaokun Liu, Bing Xiao   +9 more
doaj   +1 more source

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Harnett, M.M., Pineda, Miguel, McGrath, Mairi, Al-Riyami, Lamyaa, Pineda, M.A., Harnett, W., Pauline C. Smith, Lamyaa Al-Riyami, Harnett, Margaret, Miguel A. Pineda, Smith, P.C., Smith, Pauline, J. Alastair Gracie, Harnett, William, McGrath, M.A., Rzepecka, J., Gracie, Alastair, Rzepecka, Justyna, Margaret M. Harnett, Al-Riyami, L., Gracie, J.A., Justyna Rzepecka, Mairi A. McGrath, William Harnett   +23 more
core   +3 more sources

TCR-independent functions of Th17 cells mediated by the synergistic actions of cytokines of the IL-12 and IL-1 families. [PDF]

PLoS ONE, 2017
The development of Th17 cells is accompanied by the acquisition of responsiveness to both IL-12 and IL-23, cytokines with established roles in the development and/or function of Th1 and Th17 cells, respectively. IL-12 signaling promotes antigen-dependent
Yun Kyung Lee, Ashley E Landuyt, Stefani Lobionda, Panida Sittipo, Qing Zhao, Craig L Maynard   +5 more
doaj   +1 more source