Results 41 to 50 of about 12,148,459 (347)

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann, Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Alexandre Halaweh, Negar Farzam-kia, Negar Farzam-kia, Victoria Hannah Mamane, Victoria Hannah Mamane, Oumarou Ouédraogo, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Renaud Balthazard, Wendy Klement, Wendy Klement, Florent Lemaître, Florent Lemaître, Nathalie Arbour, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle, Catherine Larochelle   +28 more
doaj   +1 more source

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

Journal of Experimental Medicine, 2006
Th17 cells are a distinct lineage of effector CD4+ T cells characterized by their production of interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family member, at substantially higher amounts than T helper (Th)1 or Th2 ...
Spencer C. Liang, X. Tan, D. Luxenberg, Riyez Karim, K. Dunussi-joannopoulos, M. Collins, L. Fouser   +6 more
semanticscholar   +1 more source

Myeloid-derived suppressor cells promote the formation of abdominal aortic aneurysms through the IL-3-ICOSL-ICOS axis

BBA Advances, 2023
Th17 cells are powerful inflammation promoters in the pathogenesis of abdominal aortic aneurysms (AAAs). Myeloid-derived suppressor cells (MDSCs) can promote the differentiation of Th17 cells in chronic inflammatory autoimmune injury.
Li Lu, Yi Jin, Yuanhao Tong, Lun Xiao, Yayi Hou, Zhao Liu, Huan Dou   +6 more
doaj   +1 more source

Phenotypic and functional features of human Th17 cells

Journal of Experimental Medicine, 2007
T helper (Th) 17 cells represent a novel subset of CD4+ T cells that are protective against extracellular microbes, but are responsible for autoimmune disorders in mice. However, their properties in humans are only partially known.
F. Annunziato, L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta, B. Mazzinghi, E. Parente, L. Filì, S. Ferri, Francesca Frosali, F. Giudici, P. Romagnani, P. Parronchi, F. Tonelli, E. Maggi, S. Romagnani   +15 more
semanticscholar   +1 more source

Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis

Frontiers in Immunology, 2021
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with gut microbiota disequilibrium and regulatory T (Treg)/T helper 17 (Th17) immune imbalance. Stigmasterol, a plant-derived sterol, has shown anti-inflammatory effects. Our study aimed
Shuting Wen, Long He, Zhuotai Zhong, Runyuan Zhao, Senhui Weng, Hong Mi, Fengbin Liu   +6 more
semanticscholar   +1 more source

Immunobiology of IL-17A in human colorectal cancer [PDF]

, 2015
During the last decade tumor infiltration by immune cells has been recognized as a key factor determining clinical outcome. Whereas the presence within tumor tissues of defined lymphocytic populations, including cytotoxic CD8+ T cells and IFN-gamma ...
Amicarella, Francesca
core   +1 more source

Purinergic Signaling as a Regulator of Th17 Cell Plasticity. [PDF]

PLoS ONE, 2016
T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation.
Dominique Fernández, Felipe Flores-Santibáñez, Jocelyn Neira, Francisco Osorio-Barrios, Gabriela Tejón, Sarah Nuñez, Yessia Hidalgo, Maria Jose Fuenzalida, Daniel Meza, Gonzalo Ureta, Alvaro Lladser, Rodrigo Pacheco, Claudio Acuña-Castillo, Victoria Guixé, Francisco J Quintana, Maria Rosa Bono, Mario Rosemblatt, Daniela Sauma   +17 more
doaj   +1 more source

The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone

Frontiers in Immunology, 2023
T Helper 17 (Th17) cells are adaptive immune cells that play myriad roles in the body. Immune–endocrine interactions are vital in endocrine organs during pathological states.
Changyan Zi, Die Wang, Yongxiang Gao, Lisha He   +3 more
doaj   +1 more source

Sodium Chloride Drives Autoimmune Disease by the Induction of Pathogenic Th17 Cells

Nature, 2013
There has been a marked increase in the incidence of autoimmune diseases in the past half-century. Although the underlying genetic basis of this class of diseases has recently been elucidated, implicating predominantly immune-response genes, changes in ...
Markus Kleinewietfeld, A. Manzel, J. Titze, H. Kvakan, N. Yosef, R. Linker, D. Muller, D. Hafler   +7 more
semanticscholar   +1 more source

RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation

Nature Communications, 2023
Th17 cells that produce Interleukin IL-17 are pathogenic in many human diseases, including inflammatory bowel disease, but are, paradoxically, essential for maintaining the integrity of the intestinal barrier in a non-inflammatory state.
Amir Kumar Singh, Ritesh Kumar, Jianyi Yin, John F. Brooks II, Mahesh Kathania, Sandip Mukherjee, Jitendra Kumar, Kevin P. Conlon, Venkatesha Basrur, Zhe Chen, Xianlin Han, Lora V. Hooper, Ezra Burstein, K. Venuprasad   +13 more
doaj   +1 more source