Results 21 to 30 of about 12,148,459 (347)
Cell Reports, 2021 Summary: Pathogenic Th17 cells drive inflammation in autoimmune disease, yet the molecular programming underlying Th17 cell pathogenicity remains insufficiently understood.
Kathryne E. Marks +5 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2023 BackgroundParkinson’s disease (PD), which is associated to autoimmune disorders, is characterized by the pathological deposition of alpha-synuclein (α-Syn) and loss of dopaminergic (DA) neurons.
Jingwei Zhao +7 more
doaj +1 more source
Metabolic Modeling of Single Th17 Cells Reveals Regulators of Autoimmunity
Cell, 2021 Summary Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA-Seq and
Allon Wagner +25 more
semanticscholar +1 more source
Innate Immunity, 2022 Th17 cells represent important immune cells. Ursolic acid (UA) can regulate immune cell activities. This study was aimed to explore the effects of UA on Th17 cell differentiation and Schwann cell(SCs)-mediated migration and the potential mechanism. Naïve
Hua Xu +7 more
doaj +1 more source
PLoS Pathogens, 2022 Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a major health burden worldwide. CD4+ T helper cells are involved in the immune response to S. aureus by supporting antibody production and phagocytosis.
Patricia Bartsch +22 more
doaj +1 more source
The role of Th17 cells in inflammatory bowel disease and the research progress
Frontiers in Immunology, 2023 Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important
Lu Chen +5 more
semanticscholar +1 more source
Increased Proportion of Dual-Positive Th2–Th17 Cells Promotes a More Severe Subtype of Asthma
Canadian Respiratory Journal, 2021 Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma’s pathophysiological changes. Dual-positive Th2–Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce
Wenjin Sun +9 more
doaj +1 more source
Human Th17 cells: Are they different from murine Th17 cells? [PDF]
European Journal of Immunology, 2009 AbstractType 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre‐eminent cytokine of Th1 cells is IFN‐γ and that of Th2 cells is IL‐4, the distinctive cytokine of Th17 cells is IL‐17A.
ANNUNZIATO, FRANCESCO +4 more
openaire +3 more sources
Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
EMBO Reports, 2022 Increased lactate levels in the tissue microenvironment are a well‐known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial.
Aleksandra Lopez Krol +14 more
semanticscholar +1 more source
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity [PDF]
Cancer CellAnna C Cole, Chrystal M Paulos
exaly +2 more sources