Results 21 to 30 of about 4,870,412 (256)

Th17 Cells in Periodontitis and Its Regulation by A20

Frontiers in Immunology, 2021
Periodontitis is a prevalent chronic disease that results in loss of periodontal ligament and bone resorption. Triggered by pathogens and prolonged inflammation, periodontitis is modulated by the immune system, especially pro-inflammatory cells, such as ...
Ning Huang, Hao Dong, Yuqi Luo, Bin Shao
doaj   +1 more source

Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells

Cell Reports, 2020
Summary: Understanding metabolic pathways that regulate Th17 development is important to broaden therapeutic options for Th17-mediated autoimmunity.
Boyoung Shin, Gloria A. Benavides, Jianlin Geng, Sergei B. Koralov, Hui Hu, Victor M. Darley-Usmar, Laurie E. Harrington   +6 more
doaj   +1 more source

SKI Expression Suppresses Pathogenic Th17 Cell Response and Mitigates Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2021
Pathogenic Th17 cells are critically involved in many autoimmune diseases, while non-pathogenic Th17 cells are more immune regulatory. Understanding the mechanisms of the induction and maintenance of pathogenic Th17 cells will benefit the development of ...
Ping Li, Ping Li, Ping Li, Zengli Guo, Zengli Guo, Yisong Y. Wan, Yisong Y. Wan   +6 more
doaj   +1 more source

Th17 Cells in Viral Infections—Friend or Foe?

Cells, 2021
Th17 cells are recognized as indispensable in inducing protective immunity against bacteria and fungi, as they promote the integrity of mucosal epithelial barriers.
Iury Amancio Paiva, Jéssica Badolato-Corrêa, Débora Familiar-Macedo, Luzia Maria de-Oliveira-Pinto   +3 more
doaj   +1 more source

Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity. [PDF]

Cancer Cell
Cole AC, Knochelmann HM, Wyatt MM, Wittling MC, Horvat NK, Smith AS, Rangel Rivera GO, Rivera Reyes AM, Pavuluri B, Kumaresan S, Muranski P, Ruffin AT, Boss JM, Lesinski GB, Paulos CM.   +14 more
europepmc   +2 more sources

Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of IL-10-producing B cells and reduced plasma cell infiltration of the joints [PDF]

, 2014
We have previously reported that ES-62, a molecule secreted by the parasitic filarial nematode Acanthocheilonema viteae, protects mice from developing collagen-induced arthritis (CIA).
Al-Riyami, Lamyaa, Harnett, Margaret M., McGrath, Mairi A., Pineda, Miguel A., Rodgers, David T., Harnett, William   +5 more
core   +4 more sources

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann, Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Alexandre Halaweh, Negar Farzam-kia, Negar Farzam-kia, Victoria Hannah Mamane, Victoria Hannah Mamane, Oumarou Ouédraogo, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Renaud Balthazard, Wendy Klement, Wendy Klement, Florent Lemaître, Florent Lemaître, Nathalie Arbour, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle, Catherine Larochelle   +28 more
doaj   +1 more source

Th17 effector cells support B bell responses outside of germinal centres [PDF]

, 2012
Th17 cells are pro-inflammatory CD4+T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes.
David R Withers, Brewer James M., Benson, RA, David R. Withers, Paola Conigliaro, Agapitos Patakas (120270), Benson, R.A., Iain B McInnes, Patakas, A, David R. Withers (120281), Paul Garside, McInnes Iain B., Paul Garside (21184), Conigliaro, P, Withers, DR, Robert A. Benson, McInnes, I.B., CONIGLIARO, PAOLA, Patakas Agapitos, Benson Robert A., Patakas, A., Conigliaro, P., Withers David R., Agapitos Patakas, Brewer, J.M., Iain B. McInnes (120290), Robert A Benson, Paola Conigliaro (71046), Conigliaro Paola, Garside Paul, Robert A. Benson (120275), Garside, P, Mcinnes, LB, Garside, P., James M. Brewer, Iain B. McInnes, James M Brewer, Withers, D.R., Brewer, JM, James M. Brewer (120295)   +39 more
core   +1 more source

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
Suratt, Benjamin T., Weiss Daniel J., Laura Hoyt, Daggett, Rebecca, Alcorn John F., Poynter, ME, Daggett, R, Daggett Rebecca, Martin, Rebecca A., Lundblad Lennart K. A., Martin, RA, Daniel J. Weiss (460686), Ather Jennifer L., Lennart K. A. Lundblad (49082), Jennifer L. Ather (460682), Rebecca Daggett (460683), Alcorn, John F., Poynter, Matthew E., Hoyt Laura, Laura Hoyt (460684), John F. Alcorn (298001), Hoyt, L, Martin Rebecca A., Lennart K A Lundblad, Rebecca A Martin, Lundblad, Lennart K. A., Rebecca A. Martin (435571), Hoyt, Laura, Weiss, Daniel J., Poynter Matthew E., Rebecca Daggett, John F Alcorn, Alcorn, JF, Benjamin T Suratt, Suratt, BT, Ather, Jennifer L., Daniel J Weiss, Matthew E. Poynter (435575), Weiss, DJ, Lundblad, LKA, Jennifer L Ather, Benjamin T. Suratt (460685), Ather, JL, Chu, Hong Wei, Matthew E Poynter, Suratt Benjamin T.   +45 more
core   +2 more sources

Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. [PDF]

PLoS ONE, 2015
Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood.
Qing Yu, Xiang-ming Lou, Yan He
doaj   +1 more source