Results 31 to 40 of about 4,547,937 (252)

TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development

Journal of Neuroinflammation, 2019
Background Toll-like receptor 4 (TLR4) is well known for activating the innate immune system; however, it is also highly expressed in adaptive immune cells, such as CD4+ T-helper 17 (Th17) cells, which play a key role in multiple sclerosis (MS) pathology.
Xuebin Qu, Jingjing Han, Ying Zhang, Xingqi Wang, Hongbin Fan, Fang Hua, Ruiqin Yao   +6 more
doaj   +1 more source

The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment

Frontiers in Immunology, 2023
At the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both positive and negative definitive roles in the regulation of antitumor ...
Yuanyuan Pan, Wenjing Yang, Bo Tang, Xiaobo Wang, Qi Zhang, Weiping Li, Li Li   +6 more
doaj   +1 more source

Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract [PDF]

, 2010
Includes bibliographical references (leaves 85-103).T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly ...
Salkinder, Amy Leia
core   +1 more source

The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis

Viruses, 2017
The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and adaptive immunity against fungal and bacterial infections at skin and mucosal ...
Vanessa Sue Wacleche, Alan Landay, Jean-Pierre Routy, Petronela Ancuta   +3 more
doaj   +1 more source

Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance

Haematologica, 2012
Background The levels and clinical relevance of Th17 cells and other interleukin-17-producing cells have not been analyzed in chronic lymphocytic leukemia.
Preetesh Jain, Mohammad Javdan, Franziska K. Feger, Pui Yan Chiu, Cristina Sison, Rajendra N. Damle, Tawfiqul A. Bhuiya, Filiz Sen, Lynne V. Abruzzo, Jan A. Burger, Andreas Rosenwald, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Nicholas Chiorazzi, Barbara Sherry   +15 more
doaj   +1 more source

Mesenchymal stem cells repress Th17 molecular program through the PD-1 pathway. [PDF]

PLoS ONE, 2012
MSC display potent suppressive properties initially described a decade ago. More recently, MSC suppressive activities on T-cell effector pathways have been investigated.
Patricia Luz-Crawford, Danièle Noël, Ximena Fernandez, Maroun Khoury, Fernando Figueroa, Flavio Carrión, Christian Jorgensen, Farida Djouad   +7 more
doaj   +1 more source

Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. [PDF]

, 2011
Vaccination with Bacille Calmette-Guérin (BCG) has traditionally been used for protection against disease caused by the bacterium Mycobacterium tuberculosis (M.tb). The efficacy of BCG, especially against pulmonary tuberculosis (TB) is variable. The best
Minassian, Angela M, Pathan, Ansar A, Sander Clare R., Hill, Adrian, Helen A. Fletcher, Fletcher, Helen A, Natalie E R Beveridge, Hill, AVS, Minassian Angela M., Angela M Minassian, Fletcher, HA, Kristin L. Griffiths, Pathan Ansar A., Kristin L Griffiths, Hill, Adrian VS, Griffiths Kristin L., Sander, CR, Hill Adrian V. S., McShane Helen, Beveridge Natalie E. R., Pathan, AA, Minassian, AM, Clare R. Sander, Ansar A. Pathan, Hill, AV, Griffiths, KL, Beveridge, NER, Clare R Sander, Helen McShane, Ansar A Pathan, Beveridge, NE, Natalie E. R. Beveridge, Griffiths , Kristin Lisa, Griffiths, Kristin L, Sander, Clare R, Adrian V S Hill, Adrian V. S. Hill, Helen A Fletcher, Fletcher Helen A., Beveridge, Natalie ER, McShane, H, Fletcher, Helen, Angela M. Minassian, McShane, Helen   +43 more
core   +1 more source

IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]

, 2014
IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M., Katherine A. Smith, Maizels, Rick M, Rick M. Maizels, Smith, Katherine A., Smith, Katherine A   +5 more
core   +1 more source

Th17/1-Biased Inflammatory Environment Involved in the Response of Epithelial Cells to Antigen Stimuli in Nasal Polyps

Journal of Immunology Research, 2021
Several studies showed that IL-17A was significantly increased in nasal polyps (NPs). However, the source and characteristics of IL-17A-producing cells in NPs were not fully understood.
Guangfu Xu, Silong Chen, Yuchun Dong, Li Xiao   +3 more
doaj   +1 more source

miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases

Frontiers in Immunology, 2021
T helper 17 (Th17) cells are characterized by the secretion of the IL-17 cytokine and are essential for the immune response against bacterial and fungal infections.
Junxia Huang, Xinzhi Xu, Ji Yang
doaj   +1 more source