Results 31 to 40 of about 127,043 (265)
The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
Viruses, 2017 The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and adaptive immunity against fungal and bacterial infections at skin and mucosal ...
Vanessa Sue Wacleche +3 more
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Th17 Cells and Transplant Acceptance [PDF]
Transplantation, 2010 The discovery of Th17 cells has revealed a novel pathway of T-cell maturation. As with Th1 and Th2 lineages, Th17 cells promote graft pathology. However, a growing body of evidence indicates that Th17 cells may exhibit resistance to current methods of immunosuppression.
Bryna E, Burrell, D Keith, Bishop
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Mesenchymal stem cells repress Th17 molecular program through the PD-1 pathway. [PDF]
PLoS ONE, 2012 MSC display potent suppressive properties initially described a decade ago. More recently, MSC suppressive activities on T-cell effector pathways have been investigated.
Patricia Luz-Crawford +7 more
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Haematologica, 2012 Background The levels and clinical relevance of Th17 cells and other interleukin-17-producing cells have not been analyzed in chronic lymphocytic leukemia.
Preetesh Jain +15 more
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Th17 cells in autoimmune arthritis [PDF]
Annals of the Rheumatic Diseases, 2010 The role of Th17 cells in the pathogenesis of human autoimmune diseases is elusive. To gain insights into the role of Th17 cells in human autoimmune diseases, the authors analysed Th17 cells in patients with prototypic autoimmune diseases such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
Leipe, Jan +6 more
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Sox5 and Th17 cell differentiation
Oncotarget, 2015 Sox (SRY-related high-mobility-group (HMG)-box) transcription factors, which are comprised of 20 genes containing a conserved HMG DNA-binding domain, are divided into 8 groups (from A to H) according to structural homologies [reviewed in 1–2]. SoxC group, which is composed of Sox4, Sox11, and Sox12, has a HMG box domain and a transactivation domain and
Akira, Suto +2 more
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Th17 cell responses in spondyloarthritis
Best Practice & Research Clinical Rheumatology, 2017 Targeting IL-17 has become an important option in the current treatment of spondyloarthritis (SpA). To place this therapeutic advancement in context, we review the discovery and properties of this cytokine, noting those which predispose to inflammation and led to it being considered as an attractive target for the treatment of arthritis, especially SpA.
Gaston, JSH, Jadon, DR
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Th17 cells and HIV infection [PDF]
Current Opinion in HIV and AIDS, 2010 This review summarizes the recent literature about the potential perturbation and role of Th17 cells in HIV pathogenesis. We discuss the recent findings on Th17 deficiency in HIV/simian immunodeficiency virus (SIV) infection and how this deficiency may impact the mucosal host defenses, potentially contributing to chronic immune activation.Th17 cells ...
Aimee, Elhed, Derya, Unutmaz
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Frontiers in Immunology, 2019 Women have increased prevalence of Th17-mediated autoimmune diseases, including lupus and multiple sclerosis, and severe asthma. While estradiol and progesterone increased IL-17A production in Th17 cells by inhibiting Let7f miRNA expression and ...
Hubaida Fuseini +8 more
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Journal of Immunology Research, 2021 Several studies showed that IL-17A was significantly increased in nasal polyps (NPs). However, the source and characteristics of IL-17A-producing cells in NPs were not fully understood.
Guangfu Xu +3 more
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