Results 31 to 40 of about 12,148,459 (347)
Cell Reports, 2020 Summary: Understanding metabolic pathways that regulate Th17 development is important to broaden therapeutic options for Th17-mediated autoimmunity.
Boyoung Shin +6 more
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TCR-independent functions of Th17 cells mediated by the synergistic actions of cytokines of the IL-12 and IL-1 families. [PDF]
PLoS ONE, 2017 The development of Th17 cells is accompanied by the acquisition of responsiveness to both IL-12 and IL-23, cytokines with established roles in the development and/or function of Th1 and Th17 cells, respectively. IL-12 signaling promotes antigen-dependent
Yun Kyung Lee +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Pathogenic Th17 cells are critically involved in many autoimmune diseases, while non-pathogenic Th17 cells are more immune regulatory. Understanding the mechanisms of the induction and maintenance of pathogenic Th17 cells will benefit the development of ...
Ping Li +6 more
doaj +1 more source
Journal of Clinical Investigation, 2021 Estrogen deficiency causes a gut microbiome-dependent expansion of BM Th17 cells and TNF-α-producing T cells. The resulting increased BM levels of IL-17a (IL-17) and TNF stimulate RANKL expression and activity, causing bone loss.
Mingcan Yu +8 more
semanticscholar +1 more source
Cell Metabolism, 2021 SUMMARY Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD) pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic Th17 cells, however remain unknown.
Maria E. Moreno-Fernandez +20 more
semanticscholar +1 more source
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. [PDF]
PLoS ONE, 2015 Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood.
Qing Yu, Xiang-ming Lou, Yan He
doaj +1 more source
Th17 effector cells support B bell responses outside of germinal centres [PDF]
, 2012 Th17 cells are pro-inflammatory CD4+T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes.
David R Withers +39 more
core +1 more source
Induction of intestinal Th17 cells by segmented filamentous bacteria
Cell, 2009 SUMMARY The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood.
I. Ivanov +16 more
semanticscholar +1 more source
Arthritis Research & Therapy, 2008 The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmune and other chronic inflammatory disorders.
openaire +2 more sources
The Endogenous Th17 Response in NO
, 2013 Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
Suratt, Benjamin T. +45 more
core +1 more source