Results 51 to 60 of about 12,148,459 (347)

Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease

BMC Pulmonary Medicine, 2019
Background Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental plasticity, giving rise to Th17 ...
Weihan Xu, Ruimin Li, Yongchang Sun
doaj   +1 more source

The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment

Frontiers in Immunology, 2023
At the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both positive and negative definitive roles in the regulation of antitumor ...
Yuanyuan Pan, Wenjing Yang, Bo Tang, Xiaobo Wang, Qi Zhang, Weiping Li, Li Li   +6 more
doaj   +1 more source

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

Cell Reports, 2016
Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic.
Gerd Meyer zu Horste, Chuan Wu, Chao Wang, Le Cong, Mathias Pawlak, Youjin Lee, Wassim Elyaman, Sheng Xiao, Aviv Regev, Vijay K. Kuchroo   +9 more
doaj   +1 more source

Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine

Cell Host and Microbe, 2008
SUMMARY IL-17-producing T-helper cells (Th17) are potent effectors of inflammation, but little is known about the requirements for their differentiation in vivo at steady state.
I. Ivanov, Rosa de Frutos, N. Manel, K. Yoshinaga, D. Rifkin, R. Sartor, B. Finlay, D. Littman   +7 more
semanticscholar   +1 more source

Th1 and Th17 cells [PDF]

Annals of the New York Academy of Sciences, 2010
Autoreactive effector CD4+ T cells have been associated with the pathogenesis of autoimmune disorders. Early studies implicated the interferon (IFN)‐γ‐producing T helper (Th)1 subset of CD4+ cells as the causal agents in the pathogenesis of autoimmunity. However, further studies have suggested a more complex story. In models thought to be driven by Th1
Jesse M, Damsker, Anna M, Hansen, Rachel R, Caspi   +2 more
openaire   +2 more sources

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Harnett, M.M., Pineda, Miguel, McGrath, Mairi, Al-Riyami, Lamyaa, Pineda, M.A., Harnett, W., Pauline C. Smith, Lamyaa Al-Riyami, Harnett, Margaret, Miguel A. Pineda, Smith, P.C., Smith, Pauline, J. Alastair Gracie, Harnett, William, McGrath, M.A., Rzepecka, J., Gracie, Alastair, Rzepecka, Justyna, Margaret M. Harnett, Al-Riyami, L., Gracie, J.A., Justyna Rzepecka, Mairi A. McGrath, William Harnett   +23 more
core   +1 more source

TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development

Journal of Neuroinflammation, 2019
Background Toll-like receptor 4 (TLR4) is well known for activating the innate immune system; however, it is also highly expressed in adaptive immune cells, such as CD4+ T-helper 17 (Th17) cells, which play a key role in multiple sclerosis (MS) pathology.
Xuebin Qu, Jingjing Han, Ying Zhang, Xingqi Wang, Hongbin Fan, Fang Hua, Ruiqin Yao   +6 more
doaj   +1 more source

Th17 Cells in Immunity and Autoimmunity [PDF]

Clinical and Developmental Immunology, 2013
Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma.
Simone Kennedy Bedoya, Brandon Lam, Kenneth Lau, Joseph Larkin   +3 more
openaire   +3 more sources

IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]

, 2014
IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M., Katherine A. Smith, Maizels, Rick M, Rick M. Maizels, Smith, Katherine A., Smith, Katherine A   +5 more
core   +1 more source

Dysregulation of Th17 cells during the early post-transplant period in patients under calcineurin inhibitor based immunosuppression. [PDF]

PLoS ONE, 2012
Accumulating evidence suggests that Th17 cells play a role in the development of chronic allograft injury in transplantation of various organs. However, the influence of current immunosuppressants on Th17-associated immune responses has not been fully ...
Byung Ha Chung, Kyoung Woon Kim, Bo-Mi Kim, Shang Guo Piao, Sun Woo Lim, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Mi-La Cho, Chul Woo Yang   +9 more
doaj   +1 more source