Results 71 to 80 of about 12,148,459 (347)

PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

Nature Communications, 2020
Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing taxa ...
Mingcan Yu, Abdul Malik Tyagi, Jau-yi Li, Jonathan W. Adams, T. Denning, M. Weitzmann, Rheinallt M. Jones, R. Pacifici   +7 more
semanticscholar   +1 more source

Th17 cells in autoimmune arthritis [PDF]

Annals of the Rheumatic Diseases, 2010
The role of Th17 cells in the pathogenesis of human autoimmune diseases is elusive. To gain insights into the role of Th17 cells in human autoimmune diseases, the authors analysed Th17 cells in patients with prototypic autoimmune diseases such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA).
Leipe, Jan, Grunke, M., Dechant, C., Reindl, C., Kerzendorf, U., Schulze-Koops, Hendrik, Skapenko, A.   +6 more
openaire   +2 more sources

Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of IL-10-producing B cells and reduced plasma cell infiltration of the joints [PDF]

, 2014
We have previously reported that ES-62, a molecule secreted by the parasitic filarial nematode Acanthocheilonema viteae, protects mice from developing collagen-induced arthritis (CIA).
Harnett, M.M., Al-Riyami, Lamyaa, Pineda, M.A., Harnett, W., Harnett, Margaret M., Lamyaa Al-Riyami, Miguel A. Pineda, Rodgers, David T., Harnett, William, McGrath, M.A., Rodgers, D.T., David T. Rodgers, McGrath, Mairi A., Margaret M. Harnett, Al-Riyami, L., Pineda, Miguel A., Mairi A. McGrath, William Harnett   +17 more
core   +1 more source

Sox5 and Th17 cell differentiation

Oncotarget, 2015
Sox (SRY-related high-mobility-group (HMG)-box) transcription factors, which are comprised of 20 genes containing a conserved HMG DNA-binding domain, are divided into 8 groups (from A to H) according to structural homologies [reviewed in 1–2]. SoxC group, which is composed of Sox4, Sox11, and Sox12, has a HMG box domain and a transactivation domain and
Akira, Suto, Shigeru, Tanaka, Hiroshi, Nakajima   +2 more
openaire   +2 more sources

Identification of a novel population of bone marrow-derived prominin-1/CD133⁺ lung progenitors with regenerative capacity [PDF]

, 2008
Inflammation-induced lung fibrosis represents a common final pathway of various pulmonary disorders, such as the adult respiratory distress syndrome, or interstitial lung diseases, such as idiopathic pulmonary fibrosis.
Germano, Davide
core   +1 more source

Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

bioRxiv, 2019
Lymphoid cells that produce IL-17 cytokines protect barrier tissues from pathogenic microbes, but are also prominent effectors of inflammation and autoimmune disease.
June-Yong Lee, J. Hall, Lina Kroehling, Lin Wu, T. Najar, Henry Nguyen, Woan-Yu Lin, S. Yeung, H. M. Silva, Dayi Li, Ashley M. Hine, P. Loke, D. Hudesman, Jérôme C. Martin, E. Kenigsberg, M. Merad, K. Khanna, D. Littman   +17 more
semanticscholar   +1 more source

Th17 cell responses in spondyloarthritis

Best Practice & Research Clinical Rheumatology, 2017
Targeting IL-17 has become an important option in the current treatment of spondyloarthritis (SpA). To place this therapeutic advancement in context, we review the discovery and properties of this cytokine, noting those which predispose to inflammation and led to it being considered as an attractive target for the treatment of arthritis, especially SpA.
Gaston, JSH, Jadon, DR
openaire   +3 more sources

Th17 cells and HIV infection [PDF]

Current Opinion in HIV and AIDS, 2010
This review summarizes the recent literature about the potential perturbation and role of Th17 cells in HIV pathogenesis. We discuss the recent findings on Th17 deficiency in HIV/simian immunodeficiency virus (SIV) infection and how this deficiency may impact the mucosal host defenses, potentially contributing to chronic immune activation.Th17 cells ...
Aimee, Elhed, Derya, Unutmaz
openaire   +2 more sources

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans

, 2011
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ...
Di Meglio, P, Chung-Ching Chu, Francesca Capon, Di Meglio, Paola, Napolitano, Luca, Napolitano, L, Ketty Peris, Di Cesare, Antonella, Villanova, Federica, Villanova, F, Richard C. Trembath, Isabella Tosi, Paola Di Meglio, Richard C Trembath, Laggner, Ute, Chu, Chung-Ching, Chu, CC, Capon, Francesca, Federica Villanova, Frank O Nestle, Nestle, FO, Peris, K, Nestle, Frank O., Antonella Di Cesare, Peris, Ketty, Trembath, RC, Laggner, U, Tosi, Isabella, Luca Napolitano, Capon, F, Frank O. Nestle, Ute Laggner, Trembath, Richard C., Di Cesare, A, Tosi, I   +34 more
core   +1 more source

Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor beta-chain [PDF]

, 2010
Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)
Burkhardt, H, Dzhambazov, Balik, Bockermann, Robert, Bettina Sehnert, Batsalova, Tsvetelina, Harald Burkhardt, Burkhardt, Harald, Robert Bockermann, Baecklund, Johan, Batsalova, T, Bockermann, R, Dzhambazov, B, Merky, Patrick, Baecklund, J, Bäcklund, Johan, Sehnert, B, Patrick Merky, Sehnert, Bettina, Balik Dzhambazov, Tsvetelina Batsalova, Lund University., Johan Backlund, Merky, P,, Bockermann, Robert,   +23 more
core   +1 more source