Results 91 to 100 of about 12,148,459 (347)

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis

Frontiers in Immunology, 2021
Epinephrine is a hormone secreted primarily by medullary cells of the adrenal glands which regulates permeability of blood–brain barrier (BBB). Recent studies showed signaling by epinephrine/epinephrine receptor in T cells is involved in autoimmune ...
Pinguang Yang, Pinguang Yang, Hong Tian, Yong-Rui Zou, Pierre Chambon, Hiroshi Ichinose, Gerard Honig, Betty Diamond, Sun Jung Kim   +8 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

Immunity, 2019
Summary T helper 17 (Th17) cells are pathogenic in many inflammatory diseases, but also support the integrity of the intestinal barrier in a non-inflammatory manner.
Sara Omenetti, Claudio Bussi, Amina Metidji, A. Iseppon, Sunjae Lee, M. Tolaini, Y. Li, G. Kelly, P. Chakravarty, S. Shoaie, M. Gutierrez, B. Stockinger   +11 more
semanticscholar   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Stimulation of Th17-cells.

, 2021
Example of unstimulated Th17-cells (A) and stimulated Th17-cells (B) in canine peripheral blood sample of a dog suffering from intervertebral disc herniation measured by using flow cytometry.
Regina Carlson (388166), Annika Kämpe (11507012), Karl Rohn (555695), Andrea Tipold (192569), Anna Knebel (6757913)   +4 more
core   +1 more source

Helminth exposure influences Th17 plasticity, suppressing inflammatory and promoting regulatory activity by Th17 lineage cells

Frontiers in Immunology
IntroductionMany autoimmune and inflammatory-mediated diseases are driven by pathogenic Th17 responses. Infection with parasitic worms (helminths) alters host immune responses, suppresses Th17 activity and can inhibit pathogenic inflammation. Instead of
Ahmed Metwali, Ahmed Metwali, Sarah Winckler, Sarah Winckler, Xiaoqun Guan, Xiaoqun Guan, M. Nedim Ince, M. Nedim Ince, David E. Elliott, David E. Elliott   +9 more
doaj   +1 more source

Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity

Cell Reports, 2021
Summary: Sex differences in multiple sclerosis (MS) incidence and severity have long been recognized. However, the underlying cellular and molecular mechanisms for why male sex is associated with more aggressive disease remain poorly defined.
Prenitha Mercy Ignatius Arokia Doss, Muhammad Umair, Joanie Baillargeon, Reda Fazazi, Neva Fudge, Irshad Akbar, Asmita Pradeep Yeola, John B. Williams, Mickael Leclercq, Charles Joly-Beauparlant, Philippe Beauchemin, Gian Filipo Ruda, Melanie Alpaugh, Ana C. Anderson, Paul E. Brennan, Arnaud Droit, Hans Lassmann, Craig S. Moore, Manu Rangachari   +18 more
doaj   +1 more source

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source

Metabolic regulation of TH17 cells [PDF]

Molecular Immunology, 2019
IL-17-producing TH17 cells have been associated with autoimmune diseases such as multiple sclerosis (MS), psoriasis, Crohn's disease, and ulcerative colitis (Han et al., 2015), many of which lack effective therapies. Identifying effective approaches to selectively suppress TH17 cell development and function represents a legitimate strategy to cure ...
Hongxing Shen, Lewis Zhichang Shi
openaire   +2 more sources

Identification of Novel Molecular Markers of Human Th17 Cells

Cells, 2020
Th17 cells are important players in host defense against pathogens such as Staphylococcus aureus, Candida albicans, and Bacillus anthracis. Th17 cell-mediated inflammation, under certain conditions in which balance in the immune system is disrupted, is ...
Anna Sałkowska, Kaja Karaś, Iwona Karwaciak, A. Walczak-Drzewiecka, Mariusz Krawczyk, M. Sobalska-Kwapis, J. Dastych, M. Ratajewski   +7 more
semanticscholar   +1 more source