Results 81 to 90 of about 4,547,937 (252)

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Mesenchymal stem cells attenuate liver fibrosis by suppressing Th17 cells - an experimental study. [PDF]

, 2017
This study investigates molecular and cellular mechanisms involved in mesenchymal stem cell (MSC)-mediated modulation of IL-17 signaling during liver fibrosis. Mice received CCl4 (1 μl/g intraperitoneally) twice/week for 1 month.
Zana Dolicanin, Jeftic, Ilija, Neda Milosavljevic, Vladislav Volarevic, Jovicic, Nemanja, Nemanja Jovicic, Nebojsa Arsenijevic, Arsenijevic, Nebojsa, Marina Gazdic, Valentin Djonov, Lukic, Miodrag L, Djonov, Valentin, Arsenijevic, Aleksandar, Volarevic, Vladislav, Dolicanin, Zana, Simovic Markovic, Bojana, Bojana Simovic Markovic, Aleksandar Arsenijevic, Gazdic, Marina, Miodrag L. Lukic, Milosavljevic, Neda, Nurkovic, Jasmin, Ilija Jeftic, Jasmin Nurkovic   +23 more
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Cardiac Fibroblasts Recruit Th17 Cells Infiltration Into Myocardium by Secreting CCL20 in CVB3-Induced acute Viral Myocarditis

Cellular Physiology and Biochemistry, 2013
Aims: Th17 cells contributed to myocardial inflammatory injury in acute viral myocarditis (AVMC), and the migration of these cells were mainly mediated by CCL20-secreting inflammatory cells.
Miao Yu, Jun Hu, Ming-Xin Zhu, Tong Zhao, Wei Liang, Shuang Wen, Huan-Huan Li, Qi Long, Min Wang, He-Ping Guo, Xiang Cheng, Yu-Hua Liao, Jing Yuan   +12 more
doaj   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells

, 2020
International audienceMesenchymal stem cells (MSCs) exhibit potent immunoregulatory abilities by interacting with cells of the adaptive and innate immune system.
Farida Djouad, Roberto Elizondo-Vega, Luz-Crawford, Patricia, Rafael A. Contreras-López, Christian Jorgensen, Contreras-López, Rafael, Elizondo-Vega, Roberto, Djouad, Farida, Patricia Luz-Crawford, Claudia Terraza-Aguirre, Terraza-Aguirre, Claudia, Mauricio Campos-Mora, Campos-Mora, Mauricio, Jorgensen, Christian   +13 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation [PDF]

, 2015
Inflammation is a beneficial host response to infection but can contribute to inflammatory disease if unregulated. The TH17 lineage of T helper (TH) cells can cause severe human inflammatory diseases.
Esplugues, Enric, Maria Carolina Amezcua Vesely, Garmire, Lana X., Ching T, Cotton, Matthew J, de Zoete MR, Drier Y, Flavell RA, Palm, Noah W., Fan, Rong, Paiva, Ricardo S, Huber S, Bernstein, Bradley, Samuel Huber, Jens Geginat, Andrea Iseppon, Paula Licona-Limón, Stockinger B, Stockinger, Brigitta, Weaver C, Flavell, Richard A, Bernstein B, Iseppon A, Gagliani, Nicola, Iseppon, Andrea, Garmire, Lana X, Xu H, Paiva RS, de Zoete, Marcel R., Richard A. Flavell, Yotam Drier, Ricardo S. Paiva, Lana X. Garmire, Brigitta Stockinger, Xu, Hao, Huber, Samuel, Esplugues E, Amezcua Vesely MC, Palm NW, Geginat, Jens, Rong Fan, Enric Esplugues, Vesely, Maria Carolina Amezcua, Leonie Brockmann, Zi, Xiaoyuan, Xinghua Pan, Weaver, Casey, Brockmann L, Travers Ching, Ching, Travers, Gagliani N, Licona-Limón P, Brockmann, Leonie, Pan X, Nicola Gagliani, Hao Xu, I&I SIB2, Flavell, Richard A., Xiaoyuan Zi, Marcel R. de Zoete, Pan, Xinghua, Casey Weaver, Palm, Noah W, Infection & Immunity, Zi X, Fan R, Cotton MJ, Matthew J. Cotton, de Zoete, Marcel R, LS Infectiebiologie (Bacteriologie), Cotton, Matthew J., Licona-Limon, Paula, Noah W. Palm, Paiva, Ricardo S., Geginat J, Drier, Yotam, Bradley Bernstein, Garmire LX   +77 more
core   +2 more sources

Impact of the gut microbiota-Th17 cell axis on inflammatory depression

Frontiers in Psychiatry
Depression is a serious cognitive disorder that results in significant and pervasive deficits in social behavior. These deficits can be traced back to the intricate interplay between social, psychological, and biological factors. Inflammatory depression,
Xiuzhi Jia, Xiuzhi Jia, Jiayi Wang, Dan Ren, Kaibo Zhang, Hongliang Zhang, Tengchuan Jin, Tengchuan Jin, Songquan Wu, Songquan Wu   +9 more
doaj   +1 more source