Results 101 to 110 of about 4,870,412 (256)

Impact of the gut microbiota-Th17 cell axis on inflammatory depression

Frontiers in Psychiatry
Depression is a serious cognitive disorder that results in significant and pervasive deficits in social behavior. These deficits can be traced back to the intricate interplay between social, psychological, and biological factors. Inflammatory depression,
Xiuzhi Jia, Xiuzhi Jia, Jiayi Wang, Dan Ren, Kaibo Zhang, Hongliang Zhang, Tengchuan Jin, Tengchuan Jin, Songquan Wu, Songquan Wu   +9 more
doaj   +1 more source

Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation

Frontiers in Immunology, 2018
Both T cells and B cells are implicated in the pathology of multiple sclerosis (MS), but how these cells cooperate to drive disease remains unclear. Recent studies using experimental autoimmune encephalomyelitis (EAE) demonstrated that the TH17 pathway ...
James L. Quinn, James L. Quinn, Gaurav Kumar, Agnieshka Agasing, Agnieshka Agasing, Rose M. Ko, Robert C. Axtell   +6 more
doaj   +1 more source

Mesenchymal stem cells attenuate liver fibrosis by suppressing Th17 cells - an experimental study. [PDF]

, 2017
This study investigates molecular and cellular mechanisms involved in mesenchymal stem cell (MSC)-mediated modulation of IL-17 signaling during liver fibrosis. Mice received CCl4 (1 μl/g intraperitoneally) twice/week for 1 month.
Zana Dolicanin, Jeftic, Ilija, Neda Milosavljevic, Vladislav Volarevic, Jovicic, Nemanja, Nemanja Jovicic, Nebojsa Arsenijevic, Arsenijevic, Nebojsa, Marina Gazdic, Valentin Djonov, Lukic, Miodrag L, Djonov, Valentin, Arsenijevic, Aleksandar, Volarevic, Vladislav, Dolicanin, Zana, Simovic Markovic, Bojana, Bojana Simovic Markovic, Aleksandar Arsenijevic, Gazdic, Marina, Miodrag L. Lukic, Milosavljevic, Neda, Nurkovic, Jasmin, Ilija Jeftic, Jasmin Nurkovic, Arsenijevic A., Djonov V., Jovicic N, Volarevic V, Nurkovic J, Arsenijevic A, Lukic ML, Simovic Markovic B, Nurkovic J.https, Dolicanin Z., Jeftic I, Dolicanin Z, Djonov V, Arsenijevic N, Lukic, Miodrag, Gazdic M, Milosavljevic N, Milosavljevic N.   +41 more
core   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Deoxynivalenol triggered pathogenic Th17 cells subset but not regulatory Th17 (rTh17) cells in porcine jejunal explants.

, 2013
Deoxynivalenol triggered pathogenic Th17 cells subset but not regulatory Th17 (rTh17) cells in porcine jejunal explants.
Juliette Cognie (103666), Isabelle P. Oswald (103675), François Meurens (76758), Patricia M. Cano (103653), Roberta Abrami (103672), Julie Seeboth (103659), Laurence Guzylack-Piriou (103680)   +6 more
core   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Bronchoalveolar Lavage Fluid IFN-γ+ Th17 Cells and Regulatory T Cells in Pulmonary Sarcoidosis

Mediators of Inflammation, 2014
In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN-γ have been observed in peripheral blood.
Anders Tøndell, Torolf Moen, Magne Børset, Øyvind Salvesen, Anne Dorthea Rø, Malcolm Sue-Chu   +5 more
doaj   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome.

PLoS ONE, 2013
BackgroundAtherosclerosis is a chronic inflammatory disease mediated by immune cells. Th22 cells are CD4(+) T cells that secret IL-22 but not IL-17 or IFN-γ and are implicated in the pathogenesis of inflammatory disease.
Lei Zhang, Ting Wang, Xiao-qi Wang, Rui-zhi Du, Kai-ning Zhang, Xin-guang Liu, Dao-xin Ma, Shuang Yu, Guo-hai Su, Zhen-hua Li, Yu-qing Guan, Nai-li Du   +11 more
doaj   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source