Results 111 to 120 of about 79,137 (281)

Effect of PARP inhibitor in Th17 andTreg lymphocytes in experimental model of sepsis

, 2019
Introdução: A sepse é causada por uma resposta desregulada a uma infecção cujo tratamento é de suporte, inexistindo alternativas imunomoduladoras. Linfócitos T reguladores são responsáveis por limitar a inflamação, mas podem causar imunossupressão e os ...
Vieira, Juliana de Camargo
core   +1 more source

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

Differential expression of CC chemokines (CCLs) and receptors (CCRs) by human T lymphocytes in response to different Aggregatibacter actinomycetemcomitans serotypes

Journal of Applied Oral Science, 2015
In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Recently, our research group has reported a differential immunogenicity when T lymphocytes were stimulated with these different serotypes.
Carla ALVAREZ, Alvaro BENÍTEZ, Leticia ROJAS, Myriam PUJOL, Paola CARVAJAL, Jaime DÍAZ-ZÚÑIGA, Rolando VERNAL   +6 more
doaj   +1 more source

Effect of Californiconus californicus toxins on the differentiation of Regulatory T lymphocytes and Th17

, 2017
El sistema inmunológico de los vertebrados está conformado por una serie de mecanismos de defensa que desencadena acciones protectoras contra patógenos.
DANIELA ZAZUETA FAVELA
core  

The role of Th17 lymphocytes in the pathogenesis of chronic rhinosinusitis

Postępy Higieny i Medycyny Doświadczalnej
Abstract Chronic rhinosinusitis (CRS) encompasses inflammatory conditions affecting the nasal and paranasal sinus mucosa. Two major subtypes are distinguished by the presence (CRSwNP) or absence (CRSsNP) of nasal polyps. This review examines the role of T helper 17 (Th17) cells and interleukin-17 (IL-17) cytokines in CRS ...
Hanna Zielińska-Bliźniewska, Magda Cuchra-Kulesza, Alicja Nowak-Zduńczyk, Milena Paprocka-Zjawiona, Anna Merecz-Sadowska, Katarzyna Malinowska   +5 more
openaire   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

High-altitude hypoxia exacerbates dextran sulfate sodium (DSS)-induced colitis by upregulating Th1 and Th17 lymphocytes. [PDF]

Bioengineered, 2021
Gamah M, Alahdal M, Zhang Y, Zhou Y, Ji Q, Yuan Z, Han Y, Shen X, Ren Y, Zhang W.   +9 more
europepmc   +1 more source

Cigarette smoke exposure induces senescence of CD4+ Th17 lymphocytes

, 2016
Le tabagisme aggrave de nombreuses maladies inflammatoires chroniques (BPCO, maladie de Crohn, arthrite rhumatoïde, psoriasis) associées à la sous-population de lymphocytes T CD4+ (LT CD4+) inflammatoires sécrétant l’IL-17 (Th17).
Kerbrat, Stéphane
core  

Sitagliptin inhibit human lymphocytes proliferation and Th1/Th17 differentiation in vitro

European Journal of Pharmaceutical Sciences, 2017
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of anti-diabetic agents that are widely used in clinical practice to improve glycemic control in patients with type 2 diabetes. DPP-4 is also known as lymphocyte cell surface protein, CD26, and plays an important role in T-cell immunity.
Marcelo Maia, Pinheiro, Caroline Lais, Stoppa, Claudete Justina, Valduga, Cristina Eunice, Okuyama, Renata, Gorjão, Regina Mara Silva, Pereira, Susana Nogueira, Diniz   +6 more
openaire   +2 more sources

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source