Results 161 to 170 of about 113,223 (329)

Review for "Th17 lymphocytes in atypical cutaneous leishmaniasis caused by <i>Leishmania (L.) infantum chagasi</i> in Central America"

, 2020

openalex   +1 more source

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. [PDF]

, 2019
How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77-a marker of T cell antigen receptor (TCR) signaling-to identify antigen-activated CD4 T cells in the SKG mouse model ...
Ashouri, Judith F, Chen, Yiling, Cheng, Debra A, Hansen, Erik, Hsu, Lih-Yun, Lattanza, Lisa, Rychkov, Dmitry, Sirota, Marina, Weiss, Arthur, Yu, Steven, Zikherman, Julie   +10 more
core  

Transition From Psoriasis to Psoriatic Arthritis is Characterized by Distinct Alterations in Peripheral Blood Tc17, Th17, and CD4+ Effector Memory Cells

Arthritis &Rheumatology, EarlyView.
Objective Cellular mechanisms driving transition from psoriasis to psoriatic arthritis have remained largely elusive. Thus, we investigated changes within the peripheral blood T cell compartment associated with the transition phase. Methods In an observational study, 116 patients were examined and categorized into subgroups including psoriasis with at ...
Hanna Graßhoff, Sara Comdühr, Henry Nording, Jacob von Esebeck, Philine Letz, Miriam Prohaczka, Handan Gedik, Henner Zirpel, Elisabeth Spallek, Linh Ha‐Wissel, El‐Baraa Adjailia, Sabrina Arnold, Konstantinos Fourlakis, Sebastian Klapa, Ingo Eitel, Oliver J. Müller, Jens Y. Humrich, Gabriela Riemekasten, Diamant Thaçi, Peter Lamprecht   +19 more
wiley   +1 more source

Escherichia coli aggravates inflammatory response in mice oral mucositis through regulating Th17/Treg imbalance

Frontiers in Cellular and Infection Microbiology
IntroductionMicrobial dysbiosis links to mucosal immune dysregulation, but the specific bacterial contributions to oral mucosal inflammation remain unclear. Escherichia coli (E.
Jia Liu, Jia Liu, Jia Liu, Wenhui Xia, Wenhui Xia, Wenhui Xia, Wenhui Xia, Juehua Cheng, Juehua Cheng, Juehua Cheng, Yanlin Geng, Yanlin Geng, Yanlin Geng, Weiping Li, Weiping Li, Weiping Li, Yuan Fan, Yuan Fan, Yuan Fan   +18 more
doaj   +1 more source

Lymphocyte polarization: Pathophysiological relevance of Th9 and Th17

, 2018
The polarization of TCD4+ cells is one of the most important mechanisms of the immune response. Each of the subtypes or cell patterns are derived from the polarization due to the interaction of TCD4+ naive cells as antigens presented by antigen-presenting cells. The expression of certain transcription factors and the production of specific interleukins
Degasperi, Giovanna Rosa, Camargo, Ricardo Cunha, Ribeiro, Taynara Cristina Silva, Rodrigues, Thais Costa Reis, Barille, Giovanna   +4 more
openaire   +1 more source

Immunological Profiling suggests an Association between Treg dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Background Pain is the hallmark symptom of osteoarthritis (OA) and its biological drivers remain poorly understood. While the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular regulatory T cells (Tregs), is not well understood. Methods We performed omics profiling of peripheral blood from 46
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE [PDF]

, 2011
Veit Rothhammer, Sylvia Heink, Franziska Petermann, Rakesh K. Srivastava, Malte Christian Claussen, Bernhard Hemmer, Thomas Korn   +6 more
openalex   +1 more source