Results 141 to 150 of about 10,689,174 (395)

Robust Systemic and Mucosal Immune Responses to Coxsackievirus B3 Elicited by Spider Silk Protein Based Nanovaccines via Subcutaneous Immunization

open access: yesAdvanced Functional Materials, Volume 35, Issue 15, April 10, 2025.
Spider minor ampullate silk protein (MiSp) and retinoic acid (RA) based nanovaccine are capable of eliciting both mucosal and systemic immune responses following subcutaneous administration and demonstrate significant protective effects against CVB3 infection in mice.
Xingmei Qi   +4 more
wiley   +1 more source

Increased Th1/Th17 Responses Contribute to Low-Grade Inflammation in Age-Related Macular Degeneration

open access: yesCellular Physiology and Biochemistry, 2017
Background/Aims: Age-related macular degeneration (AMD) is the primary cause of senior blindness in developed countries. Mechanisms underlying initiation and development of AMD remained known.
Jiajia Chen, Wenzhan Wang, Qiuming Li
doaj   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation.

open access: yesJournal of Clinical Investigation, 1999
Allergic asthma, which is present in as many as 10% of individuals in industrialized nations, is characterized by chronic airway inflammation and hyperreactivity induced by allergen-specific Th2 cells secreting interleukin-4 (IL-4) and IL-5.
G. Hansen   +3 more
semanticscholar   +1 more source

Omnidirectional Transmissive Acoustic Metasurfaces Based on Goldberg Polyhedra

open access: yesAdvanced Functional Materials, EarlyView.
This study introduces omnidirectional acoustic metasurfaces capable of manipulating wavefronts in multiple arbitrary directions simultaneously. A full‐stack pipeline for design, optimization, and fabrication is presented to construct near‐spherical holograms based on Goldberg polyhedra.
Andrea Achilleos   +3 more
wiley   +1 more source

Regulative Differentiation as Bifurcation of Interacting Cell Population [PDF]

open access: yesarXiv, 2007
In multicellular organisms, several cell states coexist. For determining each cell type, cell-cell interactions are often essential, in addition to intracellular gene expression dynamics. Based on dynamical systems theory, we propose a mechanism for cell differentiation with regulation of populations of each cell type by taking simple cell models with ...
arxiv  

Nanozymes for Treating Ocular Diseases

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 8, March 25, 2025.
Nanozymes, with their nanoscale size and enzyme‐like activities, can reduce inflammation and oxidative stress associated with various ocular diseases. Recent research explores their integration with soft materials, nanoparticles, and drug delivery systems, promising enhanced therapeutic outcomes.
Ka‐Ying Wong   +2 more
wiley   +1 more source

Enhanced Rg3 negatively regulates Th1 cell responses

open access: yesJournal of Ginseng Research, 2019
Background: Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities.
Minkyoung Cho   +3 more
doaj  

Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model [PDF]

open access: yesarXiv, 2018
We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new
arxiv  

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden   +5 more
wiley   +1 more source

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