Results 141 to 150 of about 10,822,632 (330)

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Intrinsic STING Switches off Pathogenetic Programs of Th1 Cells to Inhibit Colitis. [PDF]

Cell Mol Gastroenterol Hepatol, 2023
Yang W, Yu T, Zhou G, Yao S, Wakamiya M, Hu H, Paessler S, Sun J, Cong Y.   +8 more
europepmc   +1 more source

Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and anembryonic pregnancies [PDF]

, 2001
Hong‐Nerng Ho, Kuang‐Han Chao, Hsin‐Fu Chen, Shee‐Uan Chen, Ming‐Yih Wu, Yu‐Shih Yang   +5 more
openalex   +1 more source

AB0564 TIGIT ACTIVATOR ALLEVIATES SYSTEMIC LUPUS ERYTHEMATOSUS BY NEGATIVELY REGULATING TH1-LIKE TREG CELL DIFFERENTIATION [PDF]

, 2023
Xiaoxiao Ma, S. Yu, Jin Gu, Hong Jiang, Y. Shan   +4 more
openalex   +1 more source

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

Proceedings of the National Academy of Sciences of the United States of America, 2015
Stacey N. Harbour, Craig L. Maynard, C. Zindl, T. Schoeb, C. Weaver   +4 more
semanticscholar   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis. [PDF]

Front Immunol, 2023
de Salles ÉM, Raeder PL, Angeli CB, Santiago VF, de Souza CN, Ramalho T, Câmara NOS, Palmisano G, Álvarez JM, D'Império Lima MR.   +9 more
europepmc   +1 more source

Itaconate regulates metabolic reprogramming of Th1 cells and alleviates acute graft-versus-host disease 3353 [PDF]

Huanle Gong, Yaoyao Shen, Yang Xu, Depei Wu   +3 more
openalex   +1 more source

The significance of Th1,Th2,Th17and treg cells in the prediction and evaluation of ulcerative colitis

, 2023
Yu Zhang, Wei Shi, Gaigai Cao, Jingru Li, Haijiao Wang, Chonghua Hao   +5 more
openalex   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source