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An Update on Human Th1 and Th2 Cells
International Archives of Allergy and Immunology, 2009The existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic cell subset has been established. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and preferential expression of some ...
ROMAGNANI, SERGIO +11 more
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Inflammatory Bowel Diseases, 1999
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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Th1 T-CELL AND MONOCYTE DEFECTS
Pediatric Clinics of North America, 2000Mutations predisposing to infections with intracellular pathogens and affecting Th1 T-cells and monocytes have been identified in the past few years. In this article, the authors review the interaction of T cells and monocytes in the context of host defense against intracellular pathogens. Known genetic defects in these pathways are summarized.
G, Uzel, S M, Holland
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Science's STKE, 2000
Immune responses can be mediated by cells (cell-mediated immunity) or through circulating factors like antibodies (humoral immunity), depending on whether naive T cells differentiate into T helper 1 (Th1) or T helper 2 (Th2) cells. Li et al .
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Immune responses can be mediated by cells (cell-mediated immunity) or through circulating factors like antibodies (humoral immunity), depending on whether naive T cells differentiate into T helper 1 (Th1) or T helper 2 (Th2) cells. Li et al .
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Crossregulation Between Th1 and Th2 Cells
Critical Reviews™ in Immunology, 1998Th1 and Th2 subsets have been characterized on the basis of the cytokines they secrete and the immune functions they mediate. Th1 cells secrete IL-2, IFN-gamma, and lymphotoxin and are important in the cell-mediated response; Th2 cells secrete IL-4, IL-5, IL-10, and IL-13 and are important in the control of macrophage function and in the stimulation of
P A, Morel, T B, Oriss
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Zeitschrift fur Rheumatologie, 2012
T helper cells contribute to the induction and maintenance of rheumatic inflammation through the secretion of cytokines. The analysis of Th1 cells expressing interferon-γ, Th17 cells expressing interleukin-17 and the newly described Th1+17 cells could give insight into the pathophysiological mechanisms of rheumatic diseases.
H-D, Chang, T, Kamradt, H, Schulze-Koops
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T helper cells contribute to the induction and maintenance of rheumatic inflammation through the secretion of cytokines. The analysis of Th1 cells expressing interferon-γ, Th17 cells expressing interleukin-17 and the newly described Th1+17 cells could give insight into the pathophysiological mechanisms of rheumatic diseases.
H-D, Chang, T, Kamradt, H, Schulze-Koops
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Trafficking of Th1 Cells to Lung
American Journal of Respiratory Cell and Molecular Biology, 2004Abstract Trafficking of lymphocytes to lung is a critical component of pulmonary immune defense and surveillance. Selectins, expressed on vascular endothelium, regulate T lymphocyte emigration into tissues, such as skin, but the role of the selectins in trafficking of T cells to lung has not been well characterized.
Joan G. Clark +6 more
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CD4+ cell memory: the enigma of Th1 cells
Trends in Molecular Medicine, 2003Despite a wealth of information pertaining to functional and phenotypic attributes of memory CD4(+) cells, the mechanisms that underlie the generation and persistence of memory in this subset are largely unknown. Recent work suggests that the development of memory might be differently regulated in T-helper-1 and T-helper-2 cells, owing to differences ...
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Biology of human TH1 and TH2 cells
Journal of Clinical Immunology, 1995Evidence is accumulating to suggest the existence of polarized human T-cell responses, reminiscent of TH1 and TH2 subsets described for mouse T cells. Human TH1 cells preferentially develop during infections by intracellular bacteria and trigger phagocyte-mediated host defense, whereas TH2 cells, which predominate during helminthic infestations and in ...
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American Journal of Reproductive Immunology, 1999
Saito S, Tsukaguchi N, Hasegawa T, Michimata T, Tsuda H, Narita N. Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells. AJRI 1999; 42:240–245 © Munksgaard, CopenhagenPROBLEM: To examine whether normal pregnancy involves type 2 T‐helper (Th2) immune condition or not.METHOD OF STUDY: We measured the ...
S, Saito +5 more
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Saito S, Tsukaguchi N, Hasegawa T, Michimata T, Tsuda H, Narita N. Distribution of Th1, Th2, and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells. AJRI 1999; 42:240–245 © Munksgaard, CopenhagenPROBLEM: To examine whether normal pregnancy involves type 2 T‐helper (Th2) immune condition or not.METHOD OF STUDY: We measured the ...
S, Saito +5 more
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