Results 171 to 180 of about 10,822,632 (330)

Liver sinusoidal endothelial cells induce immunosuppressive IL‐10‐producing Th1 cells via the Notch pathway

European Journal of Immunology, 2015
K. Neumann, Christine Rudolph, C. Neumann, M. Janke, D. Amsen, A. Scheffold   +5 more
semanticscholar   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Evolutionarily conserved IL-27β enhances Th1 cells potential by triggering the JAK1/STAT1/T-bet axis in Nile tilapia. [PDF]

Fish Shellfish Immunol Rep, 2023
Geng M, Li K, Ai K, Liang W, Yang J, Wei X.   +5 more
europepmc   +1 more source

Demethylation of the RORC2 and IL17A in Human CD4+ T Lymphocytes Defines Th17 Origin of Nonclassic Th1 Cells

Journal of Immunology, 2015
A. Mazzoni, V. Santarlasci, L. Maggi, M. Capone, M. C. Rossi, V. Querci, R. De Palma, Hyun-Dong Chang, A. Thiel, R. Cimaz, F. Liotta, L. Cosmi, E. Maggi, Andreas Radbruch, S. Romagnani, Jun Dong, F. Annunziato   +16 more
semanticscholar   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection. [PDF]

Front Immunol
Plajer V, Madrigal-Avilés A, Dzamukova M, Durán-Hernández N, Saikali P, Holecska V, Panse I, Lehmann K, Zhu J, Mashreghi MF, Hegazy AN, Peine C, Löhning M.   +12 more
europepmc   +1 more source

LncRNA RUNX1-IT1 affects the differentiation of Th1 cells by regulating NrCAM transcription in Graves' disease. [PDF]

Cell Cycle, 2022
Huang FJ, Liu YL, Wang J, Zhou YY, Zhao SY, Qin GJ.   +5 more
europepmc   +1 more source

Tofacitinib inhibits the development of experimental autoimmune uveitis and reduces the proportions of Th1 but not of Th17 cells.

, 2020
So Jin Bing, Cancan Lyu, Biying Xu, Wambui S. Wandu, Samuel J. Hinshaw, Yasuko Furumoto, Rachel R Caspi, Massimo Gadina, Igal Gery   +8 more
openalex   +1 more source

Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT.

Blood, 2015
J. Feucht, K. Opherk, P. Lang, S. Kayser, L. Hartl, W. Bethge, S. Matthes‐Martin, P. Bader, M. Albert, B. Maecker-Kolhoff, J. Greil, H. Einsele, P. Schlegel, F. Schuster, B. Kremens, C. Rossig, B. Gruhn, R. Handgretinger, T. Feuchtinger   +18 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source