Results 221 to 230 of about 320,868 (298)

Lipid Nanoparticle with 1,2-Di-O-octadecenyl-3-trimethylammonium-propane as a Component Lipid Confers Potent Responses of Th1 Cells and Antibody against Vaccine Antigen. [PDF]

ACS Nano
Kawai A, Noda M, Hirata H, Munakata L, Matsuda T, Omata D, Takemura N, Onoe S, Hirose M, Kato T, Saitoh T, Hirai T, Suzuki R, Yoshioka Y.   +13 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

Immune Imbalance in Sickle Cell Anemia: Flow Cytometric Insights Into Regulatory T Cells and Neutrophil Dynamics

Journal of Clinical Laboratory Analysis, EarlyView.
Flow cytometric analysis in sickle cell anemia reveals preserved Treg frequency despite decreased CD25 expression and increased neutrophil activity, highlighting a complex immune imbalance. The proportions of both neutrophil and lymphocyte cells have been shown to be a reliable predictor of CD3+ T cell levels, thus emphasizing the importance of innate ...
Rukiye Ölçüoğlu, Funda Tanrıkulu, Sevtap Kılınç, Eda Çakmak, Süheyl Asma, Can Boğa, Hakan Özdoğu, İlknur Pamuk   +7 more
wiley   +1 more source

Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors toAlu-like retroelements

, 2022
Millrine D, Figueras AC, Fernandez JU, Andrews R, Szomolay B, Cossins BC, Rice CM, Li J, Tyrrell VJ, McLeod L, Holmans P, O’Donnell VB, Taylor PR, Turner SJ, Jenkins BJ, Jones GW, Topley N, Williams NM, Jones SA.   +18 more
europepmc   +1 more source

Probiotic consumption reduces alveolar bone loss and kidney damage in pregnant rats with experimental periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) is a probiotic bacterial strain with immunomodulatory properties. Its benefits have been observed in healthy and systemically compromised animals with periodontitis (PD). Our objective was to investigate the local and systemic effects of the systemic administration of B.
Átila V. V. Nobre, Pedro H. F. Silva, Marina C. G. Del‐Arco, Raquel F. Gerlach, Rene S. Oliezer, José E. Tanus‐Santos, Luciene C. Figueiredo, Janaina S. A. M. Evangelista, Flávia A. C. Furlaneto, Michel R. Messora, Sérgio Luiz Salvador   +10 more
wiley   +1 more source

Author Correction: Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells. [PDF]

NPJ Vaccines
Zimmermann J, van Haren SD, Diray-Arce J, Adriawan IR, Wørzner K, Krog RT, Guleed S, Hu T, Mortensen R, Dietrich J, Solbak SMØ, Levy O, Christensen D, Pedersen GK.   +13 more
europepmc   +1 more source

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

Journal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Niyant Ganesh, Cindy Zhou, Amy Plotkin, Giacomo Baima, Massimo Costalonga, Fenfen Zhou, Hanping Feng, Priyam Jani, Jean‐Pierre Raufman, Vivek Thumbigere‐Math   +11 more
wiley   +1 more source