Results 91 to 100 of about 223,069 (306)
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
Anatomy of a Discovery: M1 and M2 Macrophages
Frontiers in Immunology, 2015 M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom.
Charles Dudley Mills
doaj +1 more source
, 1997 TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early ...
A Yabuhara (13369773) +7 more
core
Characterization of rat Th2 cells.
, 2013 CD4+ T cells were isolated and expanded using anti-CD3 and anti-CD28 co-stimulation in the presence of rhIL-2, rrIL-4, and rhIL-7 either with rapamycin (“Th2.R”) or without rapamycin (“Th2”) for 3 days.
Shoba Amarnath (37010) +6 more
core +1 more source
FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape
Advanced Science, EarlyView.FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu +14 more
wiley +1 more source
, 2019 <p>Insert : 175pb for Sample H3K4me3-WT203-Th2, 149pb for Sample H3K9ac-WT203-Th2, 171pb for Sample H3K9me3-WT203-Th2, 170pb for Sample Setdb1-WT203-Th2, 168pb for Sample Input-WT203-Th2. [C] 12 pM<br> </p> <p><strong>
Adoue Véronique
core +1 more source
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Dissecting the enigma of scleroderma: possible involvement of the kynurenine pathway
Pteridines, 2017 The kynurenine pathway (KP) is the metabolic pathway via which L-tryptophan is converted to nicotinamide. It serves important immune-regulatory roles. This article will review the evidence for involvement of the KP in scleroderma and present a possible ...
Noakes Rowland
doaj +1 more source
Polarizing T and B cell responses by APC-targeted subunit vaccines.
Frontiers in Immunology, 2015 Current influenza vaccines mostly aim at the induction of specific neutralizing antibodies. While antibodies are important for protection against a particular virus strain, T cells can recognize epitopes that will offer broader protection against ...
Gunnveig eGrødeland +3 more
doaj +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source