Results 91 to 100 of about 320,350 (302)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization

Frontiers in Immunology
BackgroundTh2 polarization is the primary characteristic of airway allergy (AA) and many other immune disorders. Further elucidation of its mechanism is necessary.
Beiping Miao, Lihua Mo, Lihua Mo, Shihan Miao, Xiwen Zhang, Haoyue Zheng, Yixuan Dong, Bailing Xie, Yuanyi Zhang, Yun Liao, Yun Liao, Yu Liu, Ping Tang, Pingchang Yang   +13 more
doaj   +1 more source

Role of eosinophils in protective immunity against secondary nematode infections

Immunological Medicine, 2019
Infections with parasites, especially those involving nematodes that invade tissues, induce a strong Th2-type immune response, which increases immunoglobulin E and eosinophil levels in the blood and tissues.
Koubun Yasuda, Etsushi Kuroda
doaj   +1 more source

Vacuum–Laser Fabrication of Programmable Soft Actuators

Advanced Science, EarlyView.
A rapid and accessible fabrication strategy for inflatable soft actuators is presented, combining vacuum sealing with laser cutting of low‐cost thermoplastic pouches. The method enables precise sealing, fast fabrication, and programmable multi‐cell geometries.
Ashkan Rezanejad, Mostafa Mousa, Yuxuan Wang, Michael Adlerstein, Junke Yao, Antonio E. Forte   +5 more
wiley   +1 more source

Indicii imunității la pacienții cu tuberculoză pulmonară sub influența tratamentului complex

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
La 49 de pacienți cu tuberculoză pulmonară asociată cu toxocaroză, care au urmat tratament standard antituberculos, antiparazitar și imunocorectiv, a fost studiată dinamica indicilor răspunsului imun Th1 și Th2 și prezența corelației IL-5 cu eozinofilia ...
Angela Guila, Natalia Zincenco, Corina Rotaru-Lungu, Serghei Ghinda, Valentina Chiroşca, Elena Privalova   +5 more
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Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT signaling of CD4+ cells

Frontiers in Pharmacology
As an inflammatory disease with a disrupted immune system, cytokine disorders in atopic dermatitis (AD) are closely related to the abnormal activation of JAK-STAT signal pathway.
Shuang Chen, Caihua Li, Caihua Li, Zeng Tu, Tao Cai, Xinying Zhang, Xinying Zhang, Lei Wang, Ruoyuan Tian, Ruoyuan Tian, Jinglan Huang, Jinglan Huang, Yuxuan Gong, Xiaotong Yang, Zetong Wu, Sirong He, Sirong He, Wenyan He, Dan Wang   +18 more
doaj   +1 more source

Evaluation of Th1 and TH2 Cytokine Network in Aspergilus Infected Tumor Bearing Mice [PDF]

Journal of Advanced Biomedical Sciences, 2012
Background & Objective: Invasive Aspergillosis is a fatal infection in immunocompromised patients. The aim of this study was to evaluate the interaction of infectious with Aspergillus and tumor on immune response and cytokine network in Aspergillus ...
Noushin Sohrabi, Majid Tebyanyan, Mehdi Mahdavi   +2 more
doaj