Results 81 to 90 of about 223,069 (306)

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells

Respiratory Research, 2021
Background Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known.
Yuqing Mo, Ling Ye, Hui Cai, Guiping Zhu, Jian Wang, Mengchan Zhu, Xixi Song, Chengyu Yang, Meiling Jin   +8 more
doaj   +1 more source

The effects of GATA3 knockdown on the gene expression of Th2-1^st, Th2-4^th and memory Th2 cells.

, 2013
The effects of GATA3 knockdown on effector Th2-1st (A), Th2-4th (B) and memory Th2 cells (C) were determined with qRT-PCR. The relative expression (GATA3/Control siRNA) levels are shown.
Hitoshi Tanaka (423113), Yutaka Suzuki (1379), Shu Horiuchi (423111), Hiroyuki Hosokawa (46662), Toshinori Nakayama (46666), Atsushi Onodera (423109), Junji Yamashita (423112), Yasumasa Ogawa (423114), Tetsuya Sasaki (423108), Yukiko Watanabe (423110)   +9 more
core   +1 more source

Chitinase and Fizz family members are a generalized feature of nematode infection with selective Upregulation of Ym1 and F10.1 by antigen-presenting cells [PDF]

, 2005
Ym1 and Fizz1 are secreted proteins that have been identified in a variety of Th2-mediated inflammatory settings. We originally found Ym1 and Fizz1 as highly expressed macrophage genes in a Brugia malayi infection model.
Coulson, P.S., Allen, J.E., Wilson, R.A., Gallagher, Iain J, Patricia S. Coulson, Judith E. Allen, Wilson, R A, P'ng Loke, Maizels, Rick M, Loke, P., Loke, P'ng, Taylor, M.D., Allen, Judith E, Nair, Meera G, Meera G. Nair, Nair, M.G., Taylor, Matthew D, Maizels, R.M., Matthew D. Taylor, Gallagher, L.J., Rick M. Maizels, Coulson, Patricia S, Iain J. Gallagher, R. A. Wilson   +23 more
core   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Th2-associated immunity to bacteria in teenagers and susceptibility to asthma

, 2010
Th2-associated immunity to bacteria in teenagers and susceptibility to ...
EM Hollams (14457882), BJ Hales (14457861), W Huvenne (13373007), PG Holt (14457411), BJ Holt (14457651), C Bachert (7727126), M Serralha (13307868), WR Thomas (14457876), PD Sly (14453628), F Parsons (13369173), S Ahlstedt (13371417), NH De Klerk (14457849)   +11 more
core  

Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function [PDF]

, 2008
Galectin-1 has been implicated in regulating T-cell survival, function, and Th1/Th2 balance in several mouse models, though the molecular and cellular basis of its immunomodulatory activity has not been completely elucidated.
Miceli, M. Carrie, Liu, Scot D., Molinder, Karen M., Poirier, Françoise, Motran, Claudia Cristina   +4 more
core   +2 more sources

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

RNA-Th2-WT-KO-Setdb1

, 2019
<p>Insert : 290pb for Sample RNA-WT195-Th2, 326pb for Sample RNA-WT203-Th2, 268pb for Sample RNA-WT208-Th2, 277pb for Sample RNA-KO201-Th2, 208pb for Sample RNA-KO209-Th2, 136pb for Sample RNA-KO210-Th2.
Adoue Veronique
core   +1 more source