Results 61 to 70 of about 170,157 (266)

Dissecting the enigma of scleroderma: possible involvement of the kynurenine pathway

Pteridines, 2017
The kynurenine pathway (KP) is the metabolic pathway via which L-tryptophan is converted to nicotinamide. It serves important immune-regulatory roles. This article will review the evidence for involvement of the KP in scleroderma and present a possible ...
Noakes Rowland
doaj   +1 more source

Polarizing T and B cell responses by APC-targeted subunit vaccines.

Frontiers in Immunology, 2015
Current influenza vaccines mostly aim at the induction of specific neutralizing antibodies. While antibodies are important for protection against a particular virus strain, T cells can recognize epitopes that will offer broader protection against ...
Gunnveig eGrødeland, Even eFossum, Bjarne eBogen, Bjarne eBogen   +3 more
doaj   +1 more source

Th2 Cytokines Inhibit Lymphangiogenesis

PLOS ONE, 2015
Lymphangiogenesis is the process by which new lymphatic vessels grow in response to pathologic stimuli such as wound healing, inflammation, and tumor metastasis. It is well-recognized that growth factors and cytokines regulate lymphangiogenesis by promoting or inhibiting lymphatic endothelial cell (LEC) proliferation, migration and differentiation. Our
Ira L Savetsky, Swapna Ghanta, Jason C Gardenier, Jeremy S Torrisi, Gabriela D García Nores, Geoffrey E Hespe, Matthew D Nitti, Raghu P Kataru, Babak J Mehrara   +8 more
openaire   +4 more sources

Extra Climate Benefits From Afforestation Due to Reduced Forest Fragmentation in China

Advanced Science, EarlyView.
Afforestation in China reduced forest fragmentation in 2015, transforming 51.8 M ha of edge forests into interior forests. This enhanced carbon sequestration (1.4±0.2 Pg CO2e, a cooling biogeochemical effect), while reduced albedo (−0.9 Pg CO2e, a warming biophysical effect) partially offset the gain, yielding a net extra climate benefit of ...
Nan Meng, Wei Li, Philippe Ciais, Martin Brandt, Xiaowei Tong, Yanzheng Yang, Guofeng Shen, Wei Du, Lei Zhu, Yi Leng, Minxuan Sun, Mengjie Han, Xuemei Zhang, Jie Zhang, Nan Wang, Dan Tong, Chao Wu, Wenhao Dong, Shu Tao, Bo Pan   +19 more
wiley   +1 more source

TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization

Frontiers in Immunology
BackgroundTh2 polarization is the primary characteristic of airway allergy (AA) and many other immune disorders. Further elucidation of its mechanism is necessary.
Beiping Miao, Lihua Mo, Lihua Mo, Shihan Miao, Xiwen Zhang, Haoyue Zheng, Yixuan Dong, Bailing Xie, Yuanyi Zhang, Yun Liao, Yun Liao, Yu Liu, Ping Tang, Pingchang Yang   +13 more
doaj   +1 more source

Role of eosinophils in protective immunity against secondary nematode infections

Immunological Medicine, 2019
Infections with parasites, especially those involving nematodes that invade tissues, induce a strong Th2-type immune response, which increases immunoglobulin E and eosinophil levels in the blood and tissues.
Koubun Yasuda, Etsushi Kuroda
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Indicii imunității la pacienții cu tuberculoză pulmonară sub influența tratamentului complex

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
La 49 de pacienți cu tuberculoză pulmonară asociată cu toxocaroză, care au urmat tratament standard antituberculos, antiparazitar și imunocorectiv, a fost studiată dinamica indicilor răspunsului imun Th1 și Th2 și prezența corelației IL-5 cu eozinofilia ...
Angela Guila, Natalia Zincenco, Corina Rotaru-Lungu, Serghei Ghinda, Valentina Chiroşca, Elena Privalova   +5 more
doaj  

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source