Медицинская иммунология, 2014 . Over last years, huge efforts are made in order to improve analytic techniques for T lymphocyte subpopulations. Appropriate studies on T-helper cells are also subject to extensive research.
S. V. Khaidukov, A. V. Zurochka
doaj +1 more source
Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity. [PDF]
PLoS ONE, 2013 Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear.
Tetsuya Sasaki +9 more
doaj +1 more source
An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment [PDF]
, 2017 Regulatory T cells (Tregs) play a pivotal role in maintaining immunological tolerance, but they can also play a detrimental role by preventing antitumor responses.
Jassem, W. +17 more
core +1 more source
Asian Pacific Journal of Tropical BiomedicineObjective: To evaluate the immunological response elicited by an inactivated bacterial vector carrying the K39 antigen of Leishmania infantum, and a purified antigen. Methods: Mice were subjected to the following treatments: (1) Purified recombinant K39 (
Araújo Lucelina S. +8 more
doaj +1 more source
Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
PLoS ONE, 2021 Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine.
Naruhito Iwasaki +6 more
doaj +1 more source
The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function [PDF]
, 2009 Parasitic worms and molecules derived from them drive Th2/Treg immune responses in mammalian hosts and have powerful anti-inflammatory properties which are shown to have therapeutic effects on inflammatory diseases.
Dowling, David J.
core +2 more sources
SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells
Respiratory Research, 2021 Background Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known.
Yuqing Mo +8 more
doaj +1 more source
Resting respiratory tract dendritic cells preferentially stimulate T helper cell Type 2(Th2) responses and require obligatory cytokine signals for induction of Th1 immunity [PDF]
, 1998 Consistent with their role in host defense, mature dendritic cells (DCs) from central lymphoid organs preferentially prime for T helper cell type 1 (Th1)-polarized immunity.
Venaille, T.J. +6 more
core
The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis [PDF]
, 2015 Objective:With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and ...
Erol Keleş +5 more
core +1 more source
, 2023 International audienceThe variant endotypes of asthma exhibit different immune signatures, and the T helper type 2 (Th2) signature predominates in children with allergic asthma, where Th2 interleukins IL-4, IL-5, and IL-13 can cause goblet cell ...
Jean‐Charles Guéry +13 more
core +1 more source