Results 41 to 50 of about 223,069 (306)

Th1/M1 conversion to Th2/M2 responses in models of inflammation lacking cell death stimulates maturation of monocyte precursors to fibroblasts

Frontiers in Immunology, 2013
We have demonstrated that cardiac fibrosis arises from the differentiation of monocyte-derived fibroblasts. We present here evidence that this process requires sequential Th1 and Th2 induction promoting analogous M1 (classically activated) and M2 ...
JoAnn eTrial, Katarzyna A. Cieslik, Sandra B. Haudek, Clemens eDuerrschmid, Mark L. Entman, Mark L. Entman   +5 more
doaj   +1 more source

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. [PDF]

The Journal of Immunology, 2007
Abstract IL-27 up-regulates Th1 but down-regulates Th2 responses. However, its molecular mechanism and regulatory effects on polarized Th2 cells remain unclear. In this study, we have revealed that IL-27 inhibits Th2 cell development as well as Th2 cytokines production from already polarized Th2 cells by down-regulation of GATA-3 and ...
Tomohiro, Yoshimoto, Takayuki, Yoshimoto, Koubun, Yasuda, Junichiro, Mizuguchi, Kenji, Nakanishi   +4 more
openaire   +3 more sources

The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype. [PDF]

, 2003
T helper cell (Th1 and Th2) associated responses were examined following a primary infection with the gastrointestinal nematode Heligmosomoides polygyrus in five inbred strains of mice with different resistance phenotypes.
Lammas, David, Lammas, D.A., Benkhe, JM, Ben-Smith, A.W., Ben-Smith, A, Lammas, DA, Behnke, JM, Behnke, Jerzy M.   +7 more
core   +1 more source

Beyond CCR7: dendritic cell migration in type 2 inflammation

Frontiers in Immunology
Conventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues
Audrey Meloun, Audrey Meloun, Beatriz León   +2 more
doaj   +1 more source

Serum Levels of Seven General Cytokines in Acute Brucellosis Before and After Treatment

Infection and Drug Resistance, 2021
Yunxia Tang,1,2,* Chenjie Ma,1,2,* Huali Sun,3 Siyuan Yang,1,2 Fengting Yu,1,2 Xingwang Li,1,2 Linghang Wang1,2 1Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Clinical Center for HIV/AIDS, Capital ...
Tang Y, Ma C, Sun H, Yang S, Yu F, Li X, Wang L   +6 more
doaj  

The Role of Food Allergy in Eosinophilic Esophagitis

Journal of Asthma and Allergy, 2020
Jeffrey M Wilson, Rung-chi Li, Emily C McGowan Division of Allergy and Immunology, University of Virginia, Charlottesville, VA, USACorrespondence: Jeffrey M WilsonDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, VA ...
Wilson JM, Li R, McGowan EC
doaj  

Role of IL-25 in Immunity [PDF]

Journal of Clinical and Diagnostic Research, 2015
IL-25 a 2o KDa protein mostly known as IL-17E, encoded by chromosome 14, and containing 117 amino acids. Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function. The receptor of IL-25 (IL-17BR)
Azar Valizadeh, Afra Khosravi, Layla Jafar Zadeh, Elaheh Gholami Parizad   +3 more
doaj   +1 more source

A Sting in the Tale of Th2 Immunity [PDF]

Immunity, 2013
Allergies are widely considered misguided Th2 cell responses. In this issue, Palm et al. (2013) and Marichal et al. (2013) show that mice mount anti-venom Th2 cell responses that share components of the "allergic" response but confer protection.
Gutierrez, Dario A., Rodewald, Hans-Reimer   +1 more
openaire   +2 more sources

Doxycycline for the treatment of breast cancer-related lymphedema

Frontiers in Pharmacology, 2022
Purpose: Secondary lymphedema is a common complication of cancer treatment for which no effective drug treatments yet exist. Level I clinical data suggests that doxycycline is effective for treating filariasis-induced lymphedema, in which it decreases ...
Stav Brown, Joseph H. Dayan, Michelle Coriddi, Leslie McGrath, Raghu P. Kataru, Babak J. Mehrara   +5 more
doaj   +1 more source

Th2 Cytokines and Atopic Dermatitis [PDF]

Journal of Clinical & Cellular Immunology, 2011
Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in prevalence around the world. Intensive research is ongoing to understand the mechanisms involved in the development of AD and offer new treatment options for patients suffering from AD.
Eric B, Brandt, Umasundari, Sivaprasad
openaire   +2 more sources