Results 151 to 160 of about 22,410 (257)

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

From Multi‐Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR‐T Cell Therapy

Advanced Science, EarlyView.
This review explores how multi‐omics, visualization technologies, and AI drive CAR‐T therapy from the micro to the macro level, from preclinical studies to clinical applications. The convergence of these approaches provides deeper insight into CAR‐T cell mechanisms, aids in structural optimization, and significantly enhances treatment efficacy and ...
Yuting Gong, Peng Fei, Yicheng Zhang, Yang Xu, Jia Wei   +4 more
wiley   +1 more source

Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis–like lesions [PDF]

, 1999
Christian Vestergaard, Hiroyuki Yoneyama, Masako Murai, Kohichiro Nakamura, Kunihiko Tamaki, Yuya Terashima, Toshio Imai, Osamu Yoshie, Tatsuro Irimura, Hitoshi Mizutani, Kouji Matsushima   +10 more
openalex   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Identification of CRTH2 as a New PPARγ-Target Gene in T Cells Suggested CRTH2 Dependent Conversion of Th2 Cells as Therapeutic Concept in COVID-19 Infection

ImmunoTargets and Therapy
Antonia Becker,1 Karoline Röhrich,1 Amanda Leske,1 Ulrike Heinicke,1 Tilo Knape,2 Aimo Kannt,2,3 Verena Trümper,4 Kai Sohn,5 Annett Wilken-Schmitz,1 Holger Neb,1 Elisabeth H Adam,1 Volker Laux,2 Michael J Parnham,2 Valerie Onasch,4 Andreas Weigert,4 Kai ...
Becker A, Röhrich K, Leske A, Heinicke U, Knape T, Kannt A, Trümper V, Sohn K, Wilken-Schmitz A, Neb H, Adam EH, Laux V, Parnham MJ, Onasch V, Weigert A, Zacharowski K, von Knethen A   +16 more
doaj  

Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis [PDF]

, 1999
Jonathan M. Spergel, Emiko Mizoguchi, Hans C. Oettgen, Atul K. Bhan, Raif S. Geha   +4 more
openalex   +1 more source

Novel Bivalent mRNA‐LNP Vaccine for Highly Effective Protection against Pneumonic Plague

Advanced Science, EarlyView.
The study investigates mRNA‐lipid nanoparticle vaccines targeting Yersinia pestis, the causative agent of plague. Combined F1+LcrV mRNA vaccination elicited robust immune responses and protected mice against virulent wild‐type and atypical strains.
Uri Elia, Yinon Levy, Hila Cohen, Ayelet Zauberman, David Gur, Inbal Hazan‐Halevy, Moshe Aftalion, Shani Benarroch, Erez Bar‐Haim, Orit Redy‐Keisar, Ofer Cohen, Dan Peer, Emanuelle Mamroud   +12 more
wiley   +1 more source

Perfis linfocitários Th1/Th2 e patogenia da co-infecção tuberculose/SIDA

, 1999
Margarida Marques, M. Fontes Baganha, Aníbal Pinto, L Vera, Leonardo Mesquita, Carlos Robalo Cordeiro, Rita Corte Real, Maria Filomena Botelho, Marli Rosa, Antonio Silvestre   +9 more
openalex   +1 more source

Inverse Design of Active‐Source Metamaterials for Thermal Camouflage with Arbitrary Active Sources

Advanced Science, EarlyView.
Active‐source metamaterials (ASM) revolutionize thermal camouflage by enabling the precise manipulation of heat signatures, transforming any active source into a desired thermal pattern. This breakthrough technology holds immense potential for infrared stealth, advanced thermal management, and energy‐efficient architecture, offering unprecedented ...
Xianrong Cao, Zifeng Tong, Yongle Nian, Jiachang Li, Yinuo Zhou, Zihao Zhang, Yixin Liu, Lei Gong, Zhengdong Cheng, Liqun He   +9 more
wiley   +1 more source

Influência dos perfis Th1/Th2 no espectro de gravidade da Tuberculose Pulmonar**Trabalho de Inverstigaçã subsidiado pelo Projecto 57/95da comissão de Foment da Inverstigação do Ministério da Saude, do qual foi Coordenadora a Dra Maria Alcide Tavares Marques.

, 1998
M. Fontes Baganha, María Aldina Marques, Aníbal Pinto, L. Vera, L. Mesqujta, Cheryl Cordeiro, Cátia Isabel Viriato Alcobia, Maria Filomena Botelho, Marli Rosa   +8 more
openalex   +1 more source