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Annals of the New York Academy of Sciences, 1996
TH2-type cytokines, particularly interleukin-5, together with granulocyte-macrophage colony-stimulating factor and interleukin-3, orchestrate the eosinophil response in asthma. Eosinophils are believed to be prime proinflammatory effector cells causing bronchial damage, which in turn, leads to chronic asthma symptoms.
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TH2-type cytokines, particularly interleukin-5, together with granulocyte-macrophage colony-stimulating factor and interleukin-3, orchestrate the eosinophil response in asthma. Eosinophils are believed to be prime proinflammatory effector cells causing bronchial damage, which in turn, leads to chronic asthma symptoms.
openaire +2 more sources
The Th1/Th2 balance in autoimmunity
Current Opinion in Immunology, 1995The study of autoimmune disease in the context of T-helper type 1 (Th1) and T-helper type 2 (Th2) CD4+ T-cell responses demonstrates that the relative contribution of either T-cell type to the development of a particular autoimmune response can influence whether or not this response leads to clinical disease.
B, Charlton, K J, Lafferty
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Clinical Immunology and Immunopathology, 1996
A large body of evidence suggests the existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic (Tc) cell subset. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and the preferential
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A large body of evidence suggests the existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic (Tc) cell subset. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and the preferential
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The TH1/TH2 paradigm in allergy
Immunotechnology, 1998Recent evidence has been accumulated to suggest that allergen-reactive type 2 helper T cells (Th2) play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, i.e. the cellular triad involved in the allergic inflammation.
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Asthma phenotyping: TH2-high, TH2-low, and beyond
Journal of Allergy and Clinical Immunology, 2014Sterk, Peter J., Lutter, René
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Redirecting Th2 Responses in Allergy
1999Atopic diseases are genetically determined disorders which affect approximately 20%–30% of the general population in developed countries and whose prevalence is increasing over the last decades. They are characterized by an enhanced ability of B lymphocytes to produce IgE antibodies in response to certain groups of otherwise innocuous environmental ...
PARRONCHI, PAOLA +2 more
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IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling
Cellular and Molecular Immunology, 2023Amber M Papillion +2 more
exaly
Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis
Frontiers in Immunology, 2022Kota Kokubo +2 more
exaly