Results 251 to 260 of about 320,350 (302)
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TH2 and ‘TH2-like’ cells in allergy and asthma: pharmacological perspectives
Trends in Pharmacological Sciences, 1994Recently, considerable progress has been made in understanding the molecular basis by which cytokines released from CD4+ helper T cells contribute to allergic disease. A subset of CD4+ helper T cells, termed TH2 cells, produce interleukin 4 (IL-4) and IL-5, but not interferon gamma.
G P, Anderson, A J, Coyle
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Immunology Today, 1997
Abstract The Th1/Th2 paradigm provides a useful model for understanding the pathogenesis of several diseases, as well as for developing novel immunotherapeutic strategies. Here, Sergio Romagnani examines Th1/Th2 polarization in the context of associated pathophysiological conditions.
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Abstract The Th1/Th2 paradigm provides a useful model for understanding the pathogenesis of several diseases, as well as for developing novel immunotherapeutic strategies. Here, Sergio Romagnani examines Th1/Th2 polarization in the context of associated pathophysiological conditions.
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Signaling pathways in Th2 development
Immunological Reviews, 2004Summary: In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell‐mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T‐helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells ...
Kerri A, Mowen, Laurie H, Glimcher
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Springer Seminars in Immunopathology, 1999
Cytokines produced by T helper (Th) cells are of critical importance for the outcome of many infectious diseases. Producing the "right" set of cytokines in response to an infectious agent can be a matter of life or death. The Th1/Th2 dichotomy, although an oversimplification has proven useful in the analysis of immune responses to infections.
C, Infante-Duarte, T, Kamradt
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Cytokines produced by T helper (Th) cells are of critical importance for the outcome of many infectious diseases. Producing the "right" set of cytokines in response to an infectious agent can be a matter of life or death. The Th1/Th2 dichotomy, although an oversimplification has proven useful in the analysis of immune responses to infections.
C, Infante-Duarte, T, Kamradt
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International archives of allergy and immunology, 1992
Human CD4+ T cell clones secreting different patterns of cytokines similar to TH1 and TH2 cells described in mice have been demonstrated. These human TH1 and TH2 clones are produced in response to different antigens and exhibit distinct functional properties. TH1 clones are produced in response to intracellular bacteria and viruses, do not provide help
ROMAGNANI, SERGIO +11 more
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Human CD4+ T cell clones secreting different patterns of cytokines similar to TH1 and TH2 cells described in mice have been demonstrated. These human TH1 and TH2 clones are produced in response to different antigens and exhibit distinct functional properties. TH1 clones are produced in response to intracellular bacteria and viruses, do not provide help
ROMAGNANI, SERGIO +11 more
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Redirecting Th2 Responses in Allergy
1999Atopic diseases are genetically determined disorders which affect approximately 20%–30% of the general population in developed countries and whose prevalence is increasing over the last decades. They are characterized by an enhanced ability of B lymphocytes to produce IgE antibodies in response to certain groups of otherwise innocuous environmental ...
PARRONCHI, PAOLA +2 more
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Th1/Th2 balance in preeclampsia
Journal of Reproductive Immunology, 2003The syndrome of preeclampsia has previously been ascribed to generalized maternal endothelial dysfunction, poor placentation and excessive maternal inflammatory response. Recent reports suggest that preeclampsia is associated with a Th1 predominant profile and may be considered as a failure of the tolerance system allowing the second physiological ...
Shigeru, Saito, Masatoshi, Sakai
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TH1-TH2: a Procrustean paradigm
Nature Immunology, 2003Although immunologists have found the dichotomous helper T cell subset model a useful construct, it is beginning to show its age. Some suggest that proponents of the TH1-TH2 dichotomy are overzealous in making the data conform to the scheme, like Procrustes who stretched or truncated his guests so that they would fit his guest bed.
Dennis O, Gor +2 more
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NLRP3 moonlights in TH2 polarization
Nature Immunology, 2015As the cytosolic guardian for many microbial and sterile inflammatory insults, NLRP3 is best appreciated for its innate immunological role mediating inflammasome activation. Now NLRP3 debuts as a transcription factor key for TH2 polarization.
Jenny P Y Ting, Jonathan A Harton
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Th2 Cells: Orchestrating Barrier Immunity
2004Publisher Summary This chapter summarizes recent insights regarding the generation of T helper (Th) 2 cells and factors regulating expression of IL-4—the canonical cytokine secreted by these cells. Th2 cells orchestrate a stereotyped cell response characterized by eosinophil and basophil infiltration, mast cell hyperplasia, and changes in epithelial ...
Daniel B, Stetson +7 more
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