Results 231 to 240 of about 223,069 (306)

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, EarlyView.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

How Does Green and AI‐Related Innovation Activity Influence Ecological Decoupling in the U.S.? Evidence From Aggregate and Industry‐Adjusted Measures

Sustainable Development, EarlyView.
ABSTRACT Managing sustainability transitions demands not only adopting the newest technology and innovations but also policy alignment that reduces ecological pressure. Linking to ecological modernization theory, this study examines the U.S. time series data spanning 1990–2023 to understand how the combined innovation activities related to green ...
Md. Rashed, Md. Kamal Uddin, Md. Naeemur Rahman, Mohammad Fakhrul Islam, A. K. M. Mohsin, Md. Faisal‐E‐Alam   +5 more
wiley   +1 more source

Nonlinear Effects of Renewable Energy Integration on Sustainable Development in OECD Countries

Sustainable Development, EarlyView.
ABSTRACT This paper examines the nonlinear relationship between the green quality of the energy mix and sustainable development in 35 OECD countries from 1995 to 2022. Unlike conventional renewable‐energy shares, the Green Quality Index (GQI) is an emissions‐weighted indicator that accounts for differences in the carbon intensity of energy sources and ...
Leping Huang, Himanshu Sekhar Panda, Shreya Pal, Mantu Kumar Mahalik, Giray Gozgor   +4 more
wiley   +1 more source

The polysaccharide Pullulan improves the initial steps of allergen‐specific immunotherapy in dogs

Veterinary Record, EarlyView.
Abstract Background Allergen‐specific immunotherapy (AIT) is the only aetiological treatment for canine atopic dermatitis (CAD). Pullulan, a polysaccharide with immunomodulatory properties, may enhance AIT outcomes when combined with allergens such as recombinant Dermatophagoides farinae 2 (Der f 2).
Franco Martini, Ana Rostaher, Claude Favrot, Nina M. Fischer   +3 more
wiley   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

Tryptophan Metabolism in Pediatric Atopic Dermatitis: Shared Mechanisms, Age-Specific Biomarkers, and Emerging Therapies. [PDF]

Biomedicines
Dyszkiewicz M, Cudowska B, Omeljaniuk WJ, Marcinkiewicz-Rybołowicz S, Lebensztejn DM.   +4 more
europepmc   +1 more source

YTHDF2 in hepatocellular carcinoma: Bridging m6A modification and cancer progression

VIEW, EarlyView.
Abstract YTH N6‐methyladenosine RNAbinding protein F2 (YTHDF2) is an N6‐methyladenosine (m6A) reader protein that mainly regulates the stability of methylated transcripts through mRNA decay. In the liver, YTHDF2 is involved in metabolic homeostasis, oxidative stress responses, and immune regulation.
Sijie Zang, Dongxue Ge, Wanqi Yang, Haobin Shen, Weihong Ge, Li Li, Dayu Chen, Jinglin Wang   +7 more
wiley   +1 more source

Emerging immune networks and targeted strategies in T2 asthma. [PDF]

Front Immunol
Xi T, Zu T, Pang X, Wu F.
europepmc   +1 more source