Results 101 to 110 of about 7,483 (199)

Medroxyprogesterone Acetate Decreases Th1, Th17, and Increases Th22 Responses via AHR Signaling Which Could Affect Susceptibility to Infections and Inflammatory Disease

Frontiers in Immunology, 2019
A synthetic progestin, medroxyprogesterone acetate (MPA), was used in a novel study to determine progestin effects on human purified macrophages and Th1, Th2, Th17, Th22 cells. MPA concentrations were equivalent to those in the serum of women after 6 and
Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Enrico Maggi, Enrico Maggi, Marylynn S. Barkley   +6 more
doaj   +1 more source

Spatially Profiling Trace Cytokine Signatures From Microscopically Derived Skin Samples to Probe Skin Disease Inflammation

Small Methods, Volume 10, Issue 13, 8 July 2026.
Inflammatory skin diseases are driven by immune dysregulation and cytokine imbalance. A challenge persists in profiling cytokines in microscopically derived biopsy skin samples due to low protein content. This study introduces a digital SERS immunoassay to simultaneously detect IL‐17A, IL‐22, IL‐23, and TNF at trace concentrations as low as 104 aM. The
Aditya Krishnakumar, Zhen Zhang, Courtney Vedelago, Timothy J. Liu, Yung‐Ching Kao, H. Peter Soyer, Mitchell S. Stark, Snehlata Kumari, Matt Trau, Alain Wuethrich   +9 more
wiley   +1 more source

High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction after Thymectomy [PDF]

, 2018
Objectives: Myasthenia gravis (MG) is an autoimmune disease accompanied by a thymic pathology and in most patients thymectomy (TE) is used as the therapeutic approach. Both B and T cells play an important role in MG pathogenesis. Methods: Twelve pre- and
Behrouz Robat-Jazi, Mina Hosseini, Marjan Mansourain, Rezaei, Abbas, Nafissi, S., Mirmosayyeb, Omid, Vahid Shaygannejad, Nafiseh Esmaeil, Omid Mirmosayyeb, Shaygannejad, Vahid, Hosseini, Mina, Robat Jazi, Behrouz, Abbas Rezaei, Esmaeil, Nafiseh, Shahriar Nafissi, Mansourain, Marjan   +15 more
core   +1 more source

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

Allergy, Volume 81, Issue 7, Page 2309-2324, July 2026.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí   +6 more
wiley   +1 more source

Rôle de l'axe TH17/TH22 dans la régulation de la réponse immune dans l'asthme allergique [PDF]

, 2013
L'asthme allergique est caractérisé par une réponse prédominante de typeTh2, mais d'autres profils tels que Th17 et Th22 sont aussi observés dans l'asthme plus sévère.
Fan, Ying
core  

Characterization of Mycobacterium tuberculosis-specific Th22 cells in HIV-TB co-infection [PDF]

, 2020
Tuberculosis (TB) remains the infectious disease causing the greatest global mortality, with an estimated 10 million incident cases of TB and 1.45 million deaths in 2018.
Makatsa, Mohau Steven
core   +1 more source

T Helper 22 Pathway Evaluation in Type 1 Diabetes and Its Complications

Iranian Journal of Allergy, Asthma and Immunology, 2018
A subset of CD4+ T cells named T helper (Th)22 cells play some pathogenic roles in some autoimmune disorders such as type 1 diabetes (T1D). We aimed to study the correlation between the circulatory number of these cells and serum levels of its related ...
Hossein Akbari, Mostafa Ghardashi, Alireza Soleimani, Hanieh Mohammadi, Hassan Nikoueinejad   +4 more
doaj  

Triple Cytokine FluoroSpot Analysis of Human Antigen-Specific IFN-γ, IL-17A and IL-22 Responses

Cells, 2014
The involvement of T-helper (Th)1, Th17 and Th22 cell subsets, in immunity, as well as in pathological inflammatory reactions, makes it important to determine their relative proportion. A triple FluoroSpot detecting the hallmark cytokines of Th1 (IFN-γ),
Tomas Dillenbeck, Eva Gelius, Jenny Fohlstedt, Niklas Ahlborg   +3 more
doaj   +1 more source

Clinical Significance of Malassezia‐Specific IgE in Assessing the Severity of Head and Neck Involvement in Korean Atopic Dermatitis Patients

Experimental Dermatology, Volume 35, Issue 7, July 2026.
ABSTRACT Head and neck dermatitis (HND) is a distinct clinical phenotype of atopic dermatitis (AD). While Malassezia sensitisation and elevated Malassezia‐specific IgE antibody (MSIA) levels have been documented in HND patients, the relationship between MSIA levels and disease severity remains controversial. The primary aim of our study was to evaluate
Han‐Na Kim, Jaewon Choi, Anna Kim, Ko Eun Kim, Yoo Sang Baek, Jiehyun Jeon   +5 more
wiley   +1 more source

Aryl hydrocarbon receptor (AhR) ligation by VAF347 promotes Th22 and inhibits Th1 polarization. [PDF]

, 2012
The Aryl hydrocarbon receptor (AhR) is a transcription factor implicated in human and murine Th22 polarization, which does not notably influence the expression of IL-17 in mice.
Rubio, Manuel, Regairaz, Camille, Sarfati, Marika, Carballido, Jose, Kenins, Linda, Woisetchlager, Maximilian, Baba, Nobuyasu   +6 more
core   +1 more source