Results 141 to 150 of about 4,589,213 (294)
Arthritis &Rheumatology, EarlyView.Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede +11 more
wiley +1 more source
Studies on coinfections with Schistosoma mansoni and Leischmania [PDF]
Schistosomiasis and visceral leishmaniasis, each responsible for serious morbidity and mortality, also have overlapping endemicities e. g. in the Sudan. Both cause granulomatous responses in the liver.
Hassan, Mohammed Fathalla
core +1 more source
The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells. [PDF]
Proc Natl Acad Sci U S A, 2023 Kumagai J +19 more
europepmc +1 more source
Arthritis &Rheumatology, EarlyView.Objective Although Takayasu arteritis (TAK) is not a prototypical autoantibody‐mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B cell activation and its contributions to TAK pathogenesis. Methods Histologic analysis of paravascular lymph nodes and affected arteries was conducted
Chenglong Fang +10 more
wiley +1 more source
Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis
Arthritis &Rheumatology, Accepted Article.Objective Systemic sclerosis (SSc) is characterized by immune dysregulation and fibrosis. We investigated whether abatacept modulates CD319/SLAMF7‐expressing cytotoxic T cells implicated in diffuse cutaneous SSc. Methods In this ancillary ASSET trial analysis, PBMCs from 67 participants were analyzed at baseline and months 1, 3, and 6.
Mikel Gurrea‐Rubio +15 more
wiley +1 more source
Early synovial regulatory T cell engagement in posttraumatic osteoarthritis
Arthritis &Rheumatology, Accepted Article.Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early post‐injury biological processes within the synovium shape disease trajectories. We investigated whether synovial regulatory T (Treg) cells are engaged during the early phase following joint injury and whether experimental enrichment ...
Xueyou Zhang +5 more
wiley +1 more source
Th2 cells infiltrating high-grade serous ovarian cancer: a feature that may account for the poor prognosis. [PDF]
J Gynecol Oncol, 2023 Su H +6 more
europepmc +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber +15 more
wiley +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu +23 more
wiley +1 more source