Results 151 to 160 of about 4,589,213 (294)

Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils. [PDF]

Br J Cancer, 2023
Jacenik D, Karagiannidis I, Beswick EJ.
europepmc   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Berberine promotes immunological outcomes and decreases neuroinflammation in the experimental model of multiple sclerosis through the expansion of Treg and Th2 cells. [PDF]

Immun Inflamm Dis, 2023
Tavaf MJ, Soltanmohammadi A, Zargarani S, Yazdanpanah E, Sadighimoghaddam B, Yousefi B, Sameni HR, Haghmorad D.   +7 more
europepmc   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

CFTR negatively reprograms Th2 cell responses, and CFTR potentiation restrains allergic airway inflammation

JCI Insight
Type 2 inflammatory diseases, including asthma, sinusitis, and allergic bronchopulmonary aspergillosis, are common in cystic fibrosis (CF). CD4+ Th2 cells promote these diseases through secretion of IL-4, IL-5, and IL-13.
Mark Rusznak, Christopher M. Thomas, Jian Zhang, Shinji Toki, Weisong Zhou, Masako Abney, Danielle M. Yanda, Allison E. Norlander, Craig A. Hodges, Dawn C. Newcomb, Mark H. Kaplan, R. Stokes Peebles Jr., Daniel P. Cook   +12 more
doaj   +1 more source

Internal Carbon Cycles in the Steel Industry: Pathways for CO2 Management and Carbon Capture Utilization

Chemie Ingenieur Technik, EarlyView.
The steel industry accounts for about 7%‐9% of global CO2 emissions. While H2‐based direct reduction is a long‐term route, near‐term solutions are needed for existing plants. Internal carbon cycles reuse steelworks off‐gases and by‐products, enabling circular carbon use and supporting CCU integration.
Florian Haakmann, Nina Kolbe, Julian Suer, Cássia Castro Müller, Nils Jäger   +4 more
wiley   +1 more source

IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells. [PDF]

J Immunol
Kania AK, Sanin DE, Gu X, Gidley M, Kokosinski E, Smith A, Pearce E, Pearce EJ.   +7 more
europepmc   +1 more source

High‐Dimensional Spectral Flow Cytometry Panel for Immunophenotypic Characterization of Fixed Whole Blood Samples

Cytometry Part A, EarlyView.
ABSTRACT Peripheral blood mononuclear cells (PBMCs) are commonly used for immune profiling in clinical research, but their isolation and cryopreservation present logistical challenges, particularly in settings with limited access to research facilities. To address this, we implemented a whole blood fixation protocol to preserve surface protein epitopes
Vaishnavi Parthasarathy, Alexander T. Heubeck, Tyanna Stuckey, Veronica Hernandez, Blessing Musgrove, Maia M. Bennett‐Boehm, Troy Torgerson, Peter Skene, Julian Reading   +8 more
wiley   +1 more source

L-Phenylalanine is a metabolic checkpoint of human Th2 cells. [PDF]

Cell Rep Med
Kulkarni AJ, Rodriguez-Coira J, Stocker N, Radzikowska U, García-Cívico AJ, Delgado Dolset MI, Contreras N, Jardón Parages I, Saiz Sanchez V, Serrano P, Izquierdo E, Gomez-Casado C, Sanchez-Solares J, Pablo-Torres C, Obeso D, Moreno-Aguilar C, Espinazo ML, Eljaszewicz A, Koch J, Baerenfaller K, Heider A, Tan G, Zhakparov D, Escribese MM, Ruiz-Leon B, Akdis CA, Argüello RJ, Barber D, Villaseñor A, Sokolowska M.   +29 more
europepmc   +1 more source