Results 191 to 200 of about 10,640,595 (395)

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Electret‐Inspired Charge‐Injected Hydrogel for Scar‐Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study presents an electret‐inspired charge‐injected self‐powered hydrogel (QOSP) for the treatment of second‐degree burn wounds infected with Staphylococcus aureus and Pseudomonas aeruginosa. The hydrogel effectively eliminates bacteria and enhances cell proliferation through electrical stimulation, thereby accelerating wound healing. Additionally,
Mujie Liu, Yuheng Wang, Haodong Wang, Lihong Qi, Yuxuan Shang, Jiajie Song, Xiulong Feng, Yiwei Chen, Waqar Ali Memon, Yuping Shen, Xiaodong Wu, Jiangbei Cao, Yifan Zhao, Zhuangde Jiang, Dingxin Liu, Shareen Shafique, Shengtao Li, Guanghao Lu, Zhixiang Wei, Zhijie Liu, Kun Zhou, Yuping Quan, Xiaoyu Zhang, Xin Zou, Xuefeng Wang, Na Liu, Yaqing Zhang, Yiwei Hu, Chao Han, Wen Wang   +29 more
wiley   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, Volume 12, Issue 17, May 8, 2025.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms [PDF]

, 1998
I‐Cheng Ho, David Lo, Laurie H. Glimcher   +2 more
openalex   +1 more source

A Spleen‐Targeted Tolerogenic mRNA‐LNPs Vaccine for the Treatment of Experimental Asthma

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Splenic DCs‐targeted co‐delivery of nucleoside‐modified antigen mRNA and Cel‐loaded LNPs vaccine induces tolerogenic DCs and subsequent antigen‐specific CD4+ regulatory T cells for the treatment of experimental allergic asthma. Abstract Lipid nanoparticles (LNPs)‐based mRNA vaccines have witnessed their great advantages in the fight against infectious ...
Fazhan Wang, Jia Lou, Xiaohan Lou, Fang Wu, Xiaoke Gao, Xiaohan Yao, Jiajia Wan, Xixi Duan, Wenjing Deng, Lixia Ma, Lijing Zhang, Guangjie He, Ming Wang, Chen Ni, Ningjing Lei, Zhihai Qin   +15 more
wiley   +1 more source

Orally Induced Peripheral Nonresponsiveness Is Maintained in the Absence of Functional Th1 or Th2 Cells [PDF]

, 1999
Hai Ning Shi, Michael J. Grusby, Cathryn Nagler‐Anderson   +2 more
openalex   +1 more source

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

Immunity, 1996
M. Kaplan, U. Schindler, S. Smiley, M. Grusby   +3 more
semanticscholar   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo. [PDF]

, 1998
Michael Lohoff, Stefan Prechtl, Frank Sommer, M Roellinghoff, Earlene M. Schmitt, Gernot Gradehandt, Peter Rohwer, Brenda D. Stride, Susan P.C. Cole, R G Deeley   +9 more
openalex   +1 more source

The Innate Immune Sensor Zbp1 Mediates Central Nervous System Inflammation Induced by Angiostrongylus Cantonensis by Promoting Macrophage Inflammatory Phenotypes

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that Zbp1 plays a pivotal role in regulating neuroimmune interactions during Angiostrongylus cantonensis (AC) infection. Zbp1 modulates lymphocyte infiltration and natural killer (NK) cell cytotoxicity by promoting cytokine secretion and M1 polarization of macrophages, shaping the CNS immune microenvironment.
Hongli Zhou, Minyu Zhou, XiPing Liao, Liangyu Zhang, Hang Wei, Yuting Lu, Yiqing Zhang, Hui Huang, Yue Hu, Tao Chen, Zhiyue Lv   +10 more
wiley   +1 more source