Results 91 to 100 of about 62,396 (288)

Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Focal epilepsy is increasingly conceptualized as a network disorder, yet the extent to which network dysfunction reflects a shared phenotype remains unknown. Spatially conserved patterns of network dysfunction may implicate a centralized mechanism underlying widespread impairment.
Joline M. Fan, Ehsan Tadayon, Kiwamu Kudo, Kamalini G. Ranasinghe, Anne M. Findlay, Robert C. Knowlton, Vikram R. Rao, Srikantan S. Nagarajan   +7 more
wiley   +1 more source

Spindle oscillations are generated in the dorsal thalamus and modulated by the thalamic reticular nucleus [PDF]

, 2008
Spindle waves occur during the early stage of slow wave sleep and are thought to arise in the thalamic reticular nucleus (TRN), causing inhibitory postsynaptic potential spindle-like oscillations in the dorsal thalamus that are propagated to the cortex ...
Chun-Hua Liu, Jufang He, Li-Xia Gao, Xian-Kai Meng, Yan-Qin Yu, Yi Ping Guo, Ying Xiong, Ying-Shing Chan   +7 more
core   +1 more source

Deep brain stimulation of the thalamus for intractable epilepsy (FRANCE study): A randomized clinical trial

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the efficacy and safety of deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) compared with best medical treatment (BMT) in patients with drug‐resistant epilepsy (DRE).
Stéphan Chabardès, Fabrice Bartolomei, Anca Nica, Claire Haegelen, Lorella Minotti, Brigitte Piallat, Chrystele Mosca, Sandrine Massicot, Sylvain Rheims, Marc Guenot, Emmanuel Cuny, Jérome Aupy, Louis Maillard, Sophie Colnat‐Coulbois, Corentin Leroy, Romain Carron, Philippe Coubes, Philippe Gélisse, Carine Karachi, Vincent Navarro, Bertrand Devaux, Francine Chassoux, Phlippe Derambure, Nicolas Reyns, Jean Christope Sol, Luc Valton, Denys Fontaine, Veronique Bourg, Philippe Kahane, Sandra David‐Tchouda, Jean Regis   +30 more
wiley   +1 more source

Defining thalamic nuclei and topographic connectivity gradients in vivo. [PDF]

, 2016
The thalamus consists of multiple nuclei that have been previously defined by their chemoarchitectual and cytoarchitectual properties ex vivo. These form discrete, functionally specialized, territories with topographically arranged graduated patterns of ...
Barrick, TR, Colman, J, Lambert, C, Simon, H   +3 more
core   +1 more source

Artificial intelligence for adaptive neuromodulation in drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects nearly one third of people with epilepsy and is associated with substantial cognitive, psychiatric, and mortality burdens. For patients who are not candidates for resection or laser interstitial thermal therapy, neuromodulation therapies such as vagus nerve stimulation, deep brain stimulation, and ...
Amir Hossein Daraie, Arianna Damiani, Mahsa Khoshkhou, Luis A. Sanchez, Rachel J. Smith, Shruti H. Agashe, Jorge A. Gonzalez‐Martinez, Jennifer Hopp, Adam S. Charles, Sridevi V. Sarma, Joon‐Yi Kang   +10 more
wiley   +1 more source

Disrupted thalamocortical functional connectivity and canonical resting-state network integration in posttraumatic stress disorder

NeuroImage: Clinical
The thalamus exhibits widespread connectivity to the entire cortical mantle, yet distinct thalamic subregions possess unique connectivity profiles and functional roles. While the thalamus has been consistently implicated in posttraumatic stress disorder (
Nick Steele, Ahmed Hussain, Delin Sun, Courtney Russell, Ashley A. Huggins, Nicholas D. Davenport, Seth G. Disner, Scott R. Sponheim, Thomas Straube, David Hofmann, Shmuel Lissek, Hannah Berg, Daniel W. Grupe, Jack B. Nitschke, Richard J. Davidson, Ruth Lanius, Maria Densmore, Jean Théberge, Richard W.J. Neufeld, Sophia I. Thomopoulos, Paul M. Thompson, Rajendra A. Morey   +21 more
doaj   +1 more source

Does Corticothalamic Feedback Control Cortical Velocity Tuning? [PDF]

, 2001
The thalamus is the major gate to the cortex and its contribution to cortical receptive field properties is well established. Cortical feedback to the thalamus is, in turn, the anatomically dominant input to relay cells, yet its influence on thalamic ...
Hillenbrand, Ulrich, van Hemmen, J. Leo
core   +3 more sources

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

Entrained cortical delta–spindle activity, not periodic synchrony, prevents arousal by NREM thalamic bursts

Communications Biology
Thalamic neurons discharge tonically during wakefulness and rapid-eye-movement (REM) sleep, but switch to burst firing during non-REM (NREM) sleep. It has been hypothesized that NREM thalamic bursts do not serve as a cortical “wake-up” signal due to ...
Xiaowei Liu, Jing Guang, Zvi Israel, Denise Wajnsztajn, Aeyal Raz, Hagai Bergman   +5 more
doaj   +1 more source

Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats [PDF]

, 2017
Rationale Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in
A Bari, A Castañé, BN Armbruster, D Dautan, EA Schilman, ER Murphy, ES Robinson, G Paxinos, GM Alexander, HD Brown, J Groenewegen, J Wess, JN Rouder, JW Dalley, K Guillem, KM Turner, LA Bradfield, M Baviera, M Bentivoglio, M Carli, M Kimura, M Pezze, ME Ragozzino, N Amitai, N Matsumoto, NM Doig, P Aldrin-Kirk, RD Rogers, S Kinomura, SV Mahler, T Minamimoto, T Robbins, TJ Stachniak, TW Faust, V Boulougouris, Y Chudasama, Y Smith   +36 more
core   +2 more sources