Results 111 to 120 of about 62,396 (288)

Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid‐positive mild cognitive impairment is associated with key clinical features

open access: yesAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Although widespread cortical asymmetries have been identified in Alzheimer's disease (AD), thalamic asymmetries and their relevance to clinical severity in AD remain unclear.
Audrey Low   +13 more
doaj   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

open access: yesEpilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira   +5 more
wiley   +1 more source

Epilepsy surgery: From bench to the clinics

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

open access: yesEpilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson   +2 more
wiley   +1 more source

Differential alterations of thalamic subregions in children and adolescents with attention deficit hyperactivity disorder and comorbid internalizing/externalizing disorders

open access: yesBMC Psychiatry
Background Attention deficit hyperactivity disorder (ADHD) is frequently accompanied by both internalizing and externalizing symptoms, yet the neuroanatomical underpinnings of these comorbidities remain unclear, particularly within thalamic subnuclei ...
Yongheng Zhao   +10 more
doaj   +1 more source

Investigating the Relationship Between Thalamic Volumes, Dementia Risk and Sleep in the PREVENT-Dementia Study

open access: yesBJPsych Open
Aims: Sleep dysfunction is common in the prodromal stages of Alzheimer’s disease. Several thalamic nuclei are implicated in promoting and maintaining sleep.
Sita Shah   +4 more
doaj   +1 more source

Expanding the scope of pediatric epilepsy surgery: Access, indications, and outcomes in a modern cohort

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Expanded indications, diagnostic tools, and treatment options have transformed the landscape of modern pediatric epilepsy surgery. Published real‐world experiences from large surgical cohorts are still needed. To close this gap, we evaluated access, indications, treatment, and outcomes in a contemporary pediatric epilepsy surgery ...
John R. McLaren   +12 more
wiley   +1 more source

Can chronic remote cortical hypoperfusion induced by thalamic infarction cause damage of tracts passing through those hypoperfused regions?

open access: yesFrontiers in Neurology, 2013
We report the case of a woman presenting with changes on cerebral imaging a year and a half after a bi-thalamic (predominantly left-sided) infarction including lateral and medial thalamic nuclei.
Eloi eMagnin   +4 more
doaj   +1 more source

Postmortem MRI reveals distinct structural features in sudden unexpected death in epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Magnetic resonance imaging (MRI) abnormalities have been reported in individuals who later die from sudden unexpected death in epilepsy (SUDEP), but their specificity and predictive value remain uncertain. Postmortem MRI (PM‐MRI) offers a unique opportunity to distinguish structural features associated with SUDEP from changes related to ...
Andrea Hill   +9 more
wiley   +1 more source

Resting state functional thalamic connectivity abnormalities in patients with post-stroke sleep apnoea: a pilot case-control study [PDF]

open access: yes, 2017
OBJECTIVE: Sleep apnoea is common after stroke, and has adverse effects on the clinical outcome of affected cases. Its pathophysiological mechanisms are only partially known.
CALISTRI, VALENTINA   +9 more
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