Results 91 to 100 of about 107,712 (298)

Alpha-thalassemia

Definitions, 2020
Alpha thalassemia major (ATM) is inherited in an autosomal recessive manner. This means that two non-functioning genes have to be passed to the fetus from each parent, resulting in loss of function of all four alpha globin genes in the fetus. A pregnancy
Alpha Thalassemia, Kevin HM Kuo
semanticscholar   +1 more source

Thalassemia [PDF]

Canadian Medical Association Journal, 2020
Hayley, Merkeley, Lauren, Bolster
openaire   +2 more sources

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia

Science Translational Medicine, 2019
Rapamycin alleviates β-thalassemia by stimulating ULK1-dependent clearance of toxic free α-globin. Unclogging red blood cells In β-thalassemia, a genetic disorder caused by mutations in the β-globin subunit of adult hemoglobin, the pathological ...
Christophe Lechauve, Julia Keith, Eugene Khandros, S. Fowler, Kalin Mayberry, Abdullah Freiwan, Christopher S. Thom, Paola Delbini, Paola Delbini, E. B. Romero, Jingjing Zhang, I. Motta, I. Motta, Heather S. Tillman, M. Cappellini, M. Cappellini, M. Kundu, M. Weiss   +17 more
semanticscholar   +1 more source

Comparative efficacy of varicocelectomy and intrauterine insemination in varicocoele patients with mild semen abnormalities: An observational study

Andrology, EarlyView.
Abstract Background Varicocoele is a common cause of male infertility, affecting spermatogenesis through increased testicular temperature, venous stasis, and oxidative stress. Microsurgical subinguinal varicocelectomy improves semen quality, whereas intrauterine insemination is widely used for mild male factor infertility.
Yanlin Ma, Weiming Deng, Tingting Wu, Qi Li, Yuanjie Li, Wenjie Mai, Lizheng Yan, Changwei Liang, Lingxiao Zhang   +8 more
wiley   +1 more source

Novel Biallelic SQSTM1 Mutation Causing a Subacute‐Onset Complex Movement Disorder with Oculomotor Abnormalities

Movement Disorders Clinical Practice, EarlyView.
Ana Luísa de Almeida Marcelino, Nina‐Maria Wilpert, Jonas Leubner, Felix Boschann, Nadja Ehmke, Christoph J. Ploner, Tina Mainka, Markus Schuelke, Andrea A. Kühn   +8 more
wiley   +1 more source

Uterine volume assay after gonadotoxic therapies in childhood, adolescence, and young adulthood: A systematic review and Bayesian network meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Recent studies have suggested the potential impact of high doses of chemotherapy on uterine volume, but this meta‐analysis did not find any significant decrease in uterine volume after chemotherapy. Abstract Introduction Uterine damage after pelvic radiotherapy or total‐body irradiation is well described, with decreased uterine volume and high ...
Eloïse Fraison, Stephanie Huberlant, Mathilde Cavalieri, Aurore Gueniffey, Justine Riss, Christine Rousset‐Jablonski, Blandine Courbiere   +6 more
wiley   +1 more source

The Hospitalisation Experience and Distress Among Jewish and Bedouin Parents of Hospitalised Children in Israel

Acta Paediatrica, EarlyView.
ABSTRACT Aim This study tested the relationship between the hospitalisation experience and distress among Jewish and Bedouin parents of hospitalised children in the south of Israel. Methods An anonymous self‐reported questionnaire containing the Distress Thermometer for Parents and the Parental Perceptions of Hospital Care in Children was completed by ...
Elena Gelman, Ayalet Noham, Ilana Livshiz‐Riven   +2 more
wiley   +1 more source

Diagnostic Value of Fructosamine and Glycosylated Hemoglobin in Estimating Blood Glucose Level in Diabetic Patients with Thalassemia Major

Medical Laboratory Journal, 2013
Background and Objective: Diabetes mellitus is one of complications that thalassemia major patients face with. Hence, blood glucose monitoring is of vital importance to these patients.
M Kosaryan, MR, A Aliasgharian, M Mousavi, P Roshan   +4 more
doaj  

The Effect of Resveratrol on Gamma Globin Gene Expression in Patients with Beta Thalassemia: The Role of Adaptation to Cellular Stress

Thalassemia Reports
HbF induction is an appropriate strategy to ameliorate the severity of β-thalassemia symptoms. Hydroxyurea (HU) is the most common chemical agent introduced as an HbF inducer but responsiveness to HU is variable and the introduction of HbF inducers ...
Hossein Jalali, Mohammad Reza Mahdavi, Mehrnoush Kosaryan, Ahmad Najafi, Aily Aliasgharian, Ebrahim Salehifar   +5 more
doaj   +1 more source