Results 131 to 140 of about 181,456 (327)

In Silico Assessment of Limited Blood Sampling Strategies for Individualised Pharmacokinetic‐guided Dosing of Efanesoctocog Alfa in Haemophilia A Patients

Haemophilia, EarlyView.
ABSTRACT Introduction Efanesoctocog alfa is a novel factor VIII (FVIII) concentrate with a unique molecular design that enables Von Willebrand Factor‐independent clearance in patients with haemophilia A. Limited sampling strategies (LSSs) are necessary to implement accurate pharmacokinetic (PK)‐guided dosing for efanesoctocog alfa in clinical practice.
Jelien den Hollander, Marjon H. Cnossen, Ron A. A. Mathôt   +2 more
wiley   +1 more source

Case report: Rethinking NGS analysis in diagnosing Diamond-Blackfan anemia syndrome

Frontiers in Genetics
Diamond-Blackfan anemia syndrome (DBAS) is a rare inherited bone marrow failure (BMF) syndrome characterized by erythroid aplasia, congenital malformations, and cancer predisposition.
Panayiota L. Papasavva, Konstantinos Kaouranis, Stefania Byrou, Constantina G. Constantinou, Iacovou Efrosini, Marina Kleanthous, Carsten W. Lederer, Thessalia Papasavva   +7 more
doaj   +1 more source

Classification ofβ-Thalassemia Carriers From Red Blood Cell Indices Using Ensemble Classifier [PDF]

, 2021
Saima Sadiq, Muhammad Usman Khalid, Mui-zzud-din, Saleem Ullah, Waqar Aslam, Arif Mehmood, Gyu Sang Choi, Byung-Won On   +7 more
openalex   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

GENETIC DISORDERS OF RED CELL GLYCOLYSIS : A REVIEW FROM THE MOLECULAR TO CLINICAL AND THERAPEUTIC APROACHES

Mediterranean Journal of Hematology and Infectious Diseases, 2014
The erythrocyte, devoid of nucleus, mitochondria,ribosomes and other organelles, has no capacity for cell replication, protein synthesis, or oxidative phosphorylation.
SOPHIA DELICOU, THEONI KANELLOPOULOU, CHRYSSANTHI KONTAXI, ARGIRI VLACHOPOULOU, ZOI PALANTZA, KONSTANTINOS MARAGKOS   +5 more
doaj  

Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis [PDF]

Hemasphere
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
El Hoss S, Lizarralde‐Iragorri M, Maciel T, Hermine O.   +3 more
europepmc   +2 more sources

The Effect of Treatment and Bone Metabolic Factors on Fracture Incidence in Patients with Thalassemia-Induced Osteoporosis: An Observational Study

, 2020
Athanasios N. Tsartsalis, George Ι. Lambrou, Eugenia Vlachou, Athanasia Samartzi, George P. Chrousos, Christina Kanaka‐Gantenbein, Antonis Kattamis   +6 more
openalex   +1 more source

Early Kidney Damage Markers after Deferasirox Treatment in Patients with Thalassemia Major: A Case-Control Study [PDF]

, 2019
Hamidreza Badeli, Adel Baghersalimi, Sajjad Eslami, Farshid Saadat, Afagh Hassanzadeh Rad, Rokhsar Basavand, Soghra Rafiei Papkiadeh, Bahram Darbandi, Wesam Kooti, Ilaria Peluso   +9 more
openalex   +1 more source

S103: TRIAL IN PROGRESS: A PHASE 2, OPEN-LABEL STUDY EVALUATING THE SAFETY AND EFFICACY OF THE PKR ACTIVATOR ETAVOPIVAT (FT-4202) IN PATIENTS WITH THALASSEMIA OR SICKLE CELL DISEASE

, 2022
Ashutosh Lal, R. Clark Brown, Thomas D. Coates, Theodosia A. Kalfa, Janet L. Kwiatkowski, Julie Brevard, Cameron C. Trenor, K. Wood, Sujit Sheth   +8 more
openalex   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source