Results 71 to 80 of about 102,550 (297)

Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia [PDF]

, 2012
This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH), based on Pluronic® block copolymers, by a new microfluidic approach.
Brognara, Eleonora, Capretto, Lorenzo, Carugo, Dario, Gambari, Roberto, Hill, Martyn, Lampronti, Ilaria, Mazzitelli, Stefania, Nastruzzi, Claudio, Zhang, Xunli   +8 more
core   +2 more sources

Medication Utilization Among Children With Sickle Cell Disease in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Objective The medication management of children with sickle cell disease (SCD), especially since the release of the 2014 National Heart, Lung, and Blood Institute (NHLBI) SCD treatment guidelines, is not well described in the published literature.
Abiodun John Ologunowa, Kelly L. Matson, Jung Eun Lee, Meghan McCormick, Mary L. Greaney, Aisling R. Caffrey   +5 more
wiley   +1 more source

Co-existence of Phenylketonuria (PKU) and beta-Thalassemia Major in a 16 Years Old Girl: A Case Report

International Journal of Hematology-Oncology and Stem Cell Research, 2012
While thalassemia major (TM) used to be a prevalent genetic disease in the past, however, Phenylketonuria (PKU) is quite rare in spite of consanquiness marriage rate of about 40% in the region. Preventive efforts for TM started >20 years ago but neonatal
Hossein Karami, Mehrnoush Kosaryan, Ail Aliasgharian, Ali Abbaskhanian, Rayka Sharifian, Mehrdad Taghipour   +5 more
doaj  

Comparative efficacy of deferiprone, deferoxamine and combination of deferiprone and deferoxamine on serum ferritin value in Beta-Thalassemia patients [PDF]

, 2015
Background: Iron overload is a predictable and life-threatening complication in patients with thalassemia. Effective and convenient iron chelation remains one of the main targets of clinical management of thalassemia major.
Amlashi, H.M., Behnampour, N., Jahazi, A., Mirbehbahani, N.   +3 more
core   +1 more source

Hot Electron Capture Dissociation Distinguishes Leucine from Isoleucine in a Novel Hemoglobin Variant, Hb Askew, β54(D5)Val→Ile [PDF]

, 2009
Population migration has led to the global dispersion of human hemoglobinopathies and has precipitated a need for their identification. An effective mass spectrometry-based procedure involves analysis of the intact α- and β-globin chains to determine ...
B. J. Wild, D. K. Rai, F. Kjeldsen, F. Kjeldsen, H. J. Cooper, J. P. Williams, J. P. Williams, N. B. Roberts, N. B. Roberts, P. Roepstorff, R. A. Zubarev, R. C. Hardison, R. H. Bateman   +12 more
core   +2 more sources

Heterozygous Beta‐Thalassaemia in Pregnancy: Two Rare Causes of Severe Fetal Anemia Requiring Intrauterine Blood Transfusions

Prenatal Diagnosis, EarlyView.
ABSTRACT Aim In this article, we present two cases of severe fetal hemolytic anemia based on a beta‐thalassaemia trait inherited from a single parent. Results These cases, presented at 20 and 28 weeks' gestation, necessitated intra‐uterine blood transfusions.
Eva van der Meij, Frans J. W. Smiers, Tamara T. Koopmann, Ingrid Krapels, Kaatje LePoole, Enrico Lopriore, Johanna M. Middeldorp, Claudia S. Ootjers, Volkher Scharnhorst, Hubertina C. J. Scheepers, Cornelis L. Harteveld, E. J. T. (Joanne) Verweij   +11 more
wiley   +1 more source

Prevalence and intensity of depression in mothers of children with beta-thalassemia major in Talghani Hospital of Gorgan, Iran [PDF]

, 2014
Background: Thalassemia is a chronic disease that it leads to psychological and social problems for parents. Mothers are at markedly increased risk of suffering from psychological distress and depression because they usually take on a considerable part ...
Jahazi, A., Karimi, M., Mirbehbahani, N., Salehi, M.   +3 more
core  

‘I Have my Beliefs, but Then I Have my Reality’: Reflections of Black and South Asian Parents Living in England on Screening and Genetic Diagnosis in Pregnancy

Prenatal Diagnosis, EarlyView.
ABSTRACT Objectives Black and South Asian women in the UK face disproportionately worse pregnancy and maternal outcomes. Yet, they are underrepresented in research. Understanding their attitudes towards prenatal tests (screening tests and diagnostic genetic tests) is critical for offering equitable prenatal care. Methods Focus groups examined attitudes
Michelle Peter, Rashida Baptiste, Rachael Buabeng, Lily Islam, Jane Fisher, Kerry Leeson‐Beevers, Melissa Hill, Lyn S. Chitty   +7 more
wiley   +1 more source

Analysis of thalassemia genotypes and HbA2 test results in pregnant women in Shenzhen, China. [PDF]

Sci Rep
To examine the thalassemia genotypes and distribution among pregnant women in Shenzhen, as well as the diagnostic value of HbA2 in thalassemia screening, in order to provide scientific evidence for thalassemia prevention and control in this region.
Qian H, Zhao W, Li W, Wu Y, Lin X, Huang J, Zhang H, Gu D.   +7 more
europepmc   +2 more sources

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source