Results 71 to 80 of about 219,391 (317)

Comparative efficacy of deferiprone, deferoxamine and combination of deferiprone and deferoxamine on serum ferritin value in Beta-Thalassemia patients [PDF]

, 2015
Background: Iron overload is a predictable and life-threatening complication in patients with thalassemia. Effective and convenient iron chelation remains one of the main targets of clinical management of thalassemia major.
Amlashi, H.M., Behnampour, N., Jahazi, A., Mirbehbahani, N.   +3 more
core   +1 more source

Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with β-thalassemia.

Blood, 2019
β-thalassemia is a hereditary disorder with limited approved treatment options; patients experience anemia and its complications, including iron overload.
A. Piga, S. Perrotta, M. Gamberini, E. Voskaridou, A. Melpignano, A. Filosa, V. Caruso, A. Pietrangelo, F. Longo, I. Tartaglione, C. Borgna-Pignatti, Xiaosha Zhang, A. Laadem, M. Sherman, K. Attie   +14 more
semanticscholar   +1 more source

Prediction of neutrophil nadir and recovery following paediatric haematopoietic cell transplantation with busulfan conditioning

British Journal of Clinical Pharmacology, EarlyView.
Aims In haematopoietic cell transplantation (HCT), neutropenia resulting from myelosuppression is an expected endpoint following busulfan‐based conditioning. However, if prolonged, neutropenia can lead to complications like serious infection and death.
Beth Apsel Winger, Joseph W. Polli, Janel Long‐Boyle, Andrew Weber, Jordan Brooks, Jaimit Parikh, Valeriu Damian   +6 more
wiley   +1 more source

Study of Pregnancy Outcome in E-Beta Thalassaemia Mothers [PDF]

, 2009
Forty eight E-Beta thalassaemia patients were studied in NRS Medical College, Kolkata, West Bengal during the period from 2000-2006. In all patients Hb% ranged from 5.2g% - 9.6g%.
Bhattacharyaya, Maitryaee, Roychowdhury, Joydeb   +1 more
core   +1 more source

Human Protein Z as the Second Known Heme‐Binding Protein from the Endogenous Blood Coagulation Inhibitor System

ChemBioChem, EarlyView.
Protein Z is a vitamin K‐dependent anticoagulant with elusive molecular functions. Herein, it is shown that heme binds to protein Z and induces conformational changes. One histidine‐based heme‐binding motif is identified. High heme‐binding affinity and functional effects are demonstrated on protein level. These findings shed new light on the structural
Paula Lindemann, Marie‐T. Hopp
wiley   +1 more source

Treatment Status of Patients with Β-Thalassemia Major in Northern Iran: Thalassemia Registry System

Iranian Journal of Public Health, 2019
Background: Electronic registry system of beta-thalassemia patients was run by Thalassemia Research Center (TRC) in 2017. The aim of the current study was presentation of therapeutic status in these patients at Mazandaran Province, Iran.
Mehrnoush KOSARYAN, Hossein KARAMI, Hadi DARVISHI-KHEZRI, Rosetta AKBARZADEH, Aily ALIASGHARIAN, Khadijeh BROMAND   +5 more
doaj   +1 more source

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis

BMC Research Notes, 2020
Objective Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment ...
Marziye Bagheri, Tina Vosoughi, Mehran Hosseinzadeh, Najmaldin Saki   +3 more
doaj   +1 more source

Bridging the Gaps in Thalassemia Care in Sri Lanka: Challenges and Way Forward. [PDF]

Public Health Chall
ABSTRACT Thalassemia is the most common monogenic disease reported in Sri Lanka and has been a major health issue for decades. Although thalassemia major is preventable, there are about 60–80 births reported annually across the country. In Sri Lanka, the majority of them are managed at government hospitals, and healthcare facilities are provided free ...
Ambillapitiya LHMRL, Waidyasuriya LSM, Weerakoon DCR, Rathnayake RMPM, Jayasekara JMKB, Damayanthi HDWT, Dorji T, Lucero-Prisno DE.   +7 more
europepmc   +2 more sources

Prevalence of Inherited Hemoglobin Disorders and Relationships with Anemia and Micronutrient Status among Children in Yaoundé and Douala, Cameroon. [PDF]

, 2017
Information on the etiology of anemia is necessary to design effective anemia control programs. Our objective was to measure the prevalence of inherited hemoglobin disorders (IHD) in a representative sample of children in urban Cameroon, and examine the ...
Brown, Kenneth H, Engle-Stone, Reina, Gimou, Marie-Madeleine, Green, Ralph, Nankap, Martin, Ndjebayi, Alex, Oyono, Yannick, Tarini, Ann, Williams, Thomas N   +8 more
core   +1 more source

The impact of low‐dose aspirin on hemoglobin levels in pregnancy: A secondary analysis of a randomized controlled trial for prevention of hypertensive disorders of pregnancy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objectives This study evaluates the association of low‐dose aspirin (LDA) with hemoglobin (Hb) levels during pregnancy and explores how changes in Hb levels relate to hypertensive disorders of pregnancy (HDP). Methods This secondary analysis of a randomized controlled trial comprised 249 pregnant women recruited from a regional hospital in ...
N. M. Ngcobo, V. Dorsamy, C. Bagwandeen, P. Z. Mkhize, J. Moodley   +4 more
wiley   +1 more source