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Classical meets malignant hematology: a case of acquired εγδβ-thalassemia in clonal hematopoiesis [PDF]

Haematologica
Hemoglobinopathies including thalassemias are among the most frequent genetic disorders worldwide. Primarily, these entities result from germline variants in the globin gene clusters and their cis-acting regulatory elements, and thus the WHO classifies ...
Armin P. Piehler, Marietta Truger, Jan-Hendrik Kozik, Sandra Weissmann, Martin Schwonzen, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Gregor Hoermann, Claudia Haferlach   +9 more
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Thalassemia

Trends in Pediatrics, 2021
Defects in protein structure or synthesis of hemoglobin are called hemoglobinopathies. Thalassemia is the most common hemoglobinopathy, and it is estimated that 5% of the world population carries at least one variant allele of thalassemia.
Tekin Aksu, Sule Unal
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Incidence Trends of Inherited Anemias at the Global, Regional, and National Levels Over Three Decades [PDF]

Journal of Epidemiology and Global Health, 2023
Inherited anemia continues to pose a significant public health concern on a global scale, owing to its extensive geographical prevalence, substantial patient population, and profound ramifications.
Hongwei Tang, Nan Zhang, Xinlei Liu, Hongbo Xiao, Hanyue Zhang, Kang Zhou, Jianchuan Deng   +6 more
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Thalassemia, a human blood disorder

Brazilian Journal of Biology, 2021
A group of inherited blood defects is known as Thalassemia is among the world’s most prevalent hemoglobinopathies. Thalassemias are of two types such as Alpha and Beta Thalassemia. The cause of these defects is gene mutations leading to low levels and/or
F. Shafique, S. Ali, T. Almansouri, F. Van Eeden, N. Shafi, M. Khalid, S. Khawaja, S. Andleeb, M. ul Hassan   +8 more
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Thalassemias in South Asia: clinical lessons learnt from Bangladesh

Orphanet Journal of Rare Diseases, 2017
Thalassemias are emerging as a global public health concern. Due to remarkable success in the reduction of childhood mortality by controlling infectious diseases in developing countries, thalassemias are likely to be a major public health concern in the ...
Mohammad Sorowar Hossain, Enayetur Raheem, Tanvira Afroze Sultana, Shameema Ferdous, Nusrat Nahar, Sazia Islam, Mohammad Arifuzzaman, Mohammad Abdur Razzaque, Rabiul Alam, Sonia Aziz, Hazera Khatun, Abdur Rahim, Manzur Morshed   +12 more
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Oro-dental clinical aspects in children with thalassemia [PDF]

Archives of the Balkan Medical Union, 2019
Introduction. Thalassemias are the most common monogenic diseases. They are divided in two major categories: alpha – thalassemias (minor thalassemia), that do not have a special symptomatology and beta-thalassemias, which are a form of hereditary disease
Andrei KOZMA, Florentina VLADAREANU, Doriana AGOP-FORNA, Andreea D. IORDAN DUMITRU, Claudiu TOPOLICEANU   +4 more
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Recent advances in gene therapy for thalassemia

Journal of Pharmacy and Bioallied Sciences, 2012
Thalassemias are genetically transmitted disorders. Depending upon whether the genetic defects or deletion lies in transmission of α or β globin chain gene, thalassemias are classified into α and β-thalassemias.
J V Raja, M A Rachchh, R H Gokani
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ENERCA: e-learning platform

Thalassemia Reports, 2014
ENERCA (the European Network for Rare and Congenital Anemias) is a European Commission funded project since 2002. Rare anaemias in Europe comprise haemoglobin disorders, such as thalassemias or sickle cell disease, and other rarer disorders, including ...
Patricia Aguilar-Martínez
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A demographic prevalence of β Thalassemia carrier and other hemoglobinopathies in adolescent of Tharu population

Journal of Family Medicine and Primary Care, 2020
Background and Aims: Hemoglobinopathies and thalassemias are the commonest single gene disorders in India. In Terai region of India, Hemoglobinopathies and thalassemias are the most common in the Tharu community.
Nitu Nigam, Rashmi Kushwaha, Geeta Yadav, Prithvi K Singh, Nitin Gupta, Bhupendra Singh, Monica Agrawal, Pooran Chand, Shailedra K Saxena, Madan Lal Brahma Bhatt   +9 more
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Molecular patterns of β-thalassemia mutations of Saudi patients referred to King Faisal Specialist Hospital and Research Center

Journal of Applied Hematology, 2017
Background: Beta thalassemias are a group of hereditary blood disorders that are characterized by reduction or complete absence of the β-globin chain synthesis due to mutations, affecting critical areas of the β-globin gene on the chromosome 11.
Ayman Mashi, Haitham Khogeer, Adnan khyatte, Halah Abalkhail, Salem Khalil   +4 more
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