Results 91 to 100 of about 4,160 (239)

Free Fetal DNA Testing to Guide Early Intervention in the Management of the Kell Alloimmunized Pregnancy

Prenatal Diagnosis, EarlyView.
Kenneth J. Moise Jr, Thomas Trevett, Stephanie Moench, Erin Moise   +3 more
wiley   +1 more source

Comparative detection of red cell alloantibodies by solid‐phase red cell adherence and column agglutination technology in routine pre‐transfusion testing

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Detection of clinically significant alloantibodies (CSAs), particularly weak or weakly reactive antibodies, remains challenging with conventional agglutination methods and may contribute to delayed haemolytic transfusion reactions (DHTRs).
Rasika Dhawan Setia, Mitu Dogra, Amena Ebadur Rahman, Vadad Khaleeq, Deepa Tiwari   +4 more
wiley   +1 more source

Neonatal screening of beta-thalassemias by thin-layer isoelectric focusing

, 1982
As an alternative to the recently proposed screening for β-thalassemias by isoelectric focusing (IEF) of denatured globin chains in urea-detergent gels [6], IEF of intact hemoglobins, obtained from umbilical cord blood in neonatal units, is reported here.
G. Cossu, P. G. Righetti, M. Manca, R. Bullitta, A. Bianchi Bosisio, P. M. Gavina, E. Gianazza, Renza Bullitta, Elisabetta Gianazza, Mario Manca, Gianfranco Cossu, Adriana Bianchi Bosisio, Pier Giorgio Righetti, M. Gavina Pirastru   +13 more
core   +1 more source

Knockdown of mitotically associated long non‐coding RNA dysregulates endothelial functions, transcriptome and proteome

The Journal of Physiology, EarlyView.
Abstract figure legend Downregulation of mitotically associated long non‐coding RNA (MANCR) disturbs transcriptome and proteome in endothelial cells, possibly leading to endothelial and vascular dysfunction in preeclampsia. Abstract Preeclampsia (PE) is a hypertensive disorder during pregnancy, which is characterized by a wide spectrum of endothelial ...
Si‐Yan Zhang, Chi Zhou, Jing Zheng
wiley   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 12, Page 2961-2975, December 2026.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source

Silent thalassemias: genotypes and phenotypes

Haematologica, 1997
BACKGROUND AND OBJECTIVE: Current application of molecular biology techniques to the study of the DNA of globin genes has confirmed the existence of silent alpha and beta thalassemias; which had already been reported on the basis of red blood cell ...
I Bianco, MP Cappabianca, E Foglietta, M Lerone, G Deidda, L Morlupi, P Grisanti, D Ponzini, S Rinaldi, B Graziani   +9 more
doaj  

Racial disparities in anaemia associated with paediatric chronic kidney disease

British Journal of Haematology, EarlyView.
Manya Raina, Shay Tanna, Brandon H. Lee, Bradley A. Warady   +3 more
wiley   +1 more source

Impact of Heat Block Drying on Morphologic Preservation and Staining of Peripheral Blood Smears

International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1341-1347, December 2026.
ABSTRACT Introduction Morphologic evaluation of the peripheral blood smear is critical for diagnosis and ruling out certain hematologic disorders. While air‐drying is standard, some laboratories may use heat blocks to expedite drying. Excessive heat may induce morphologic artifacts, but there is a lack of systematic literature on this practice ...
Ryan C. Shean, Nicolas Mavromatis, Gary Isom, Angie Turnbow, Lauren Pearson   +4 more
wiley   +1 more source

The population genetics and dynamics of the thalassemias.

, 2010
The inherited disorders of hemoglobin, including the thalassemias, are by far the commonest monogenic diseases. Although several factors are responsible for their very high frequency, the major mechanism seems to be natural selection mediated by ...
A. O’Donnell, D.J. Weatherall, S.J. Allen, T.N. Williams   +3 more
core   +1 more source

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, Volume 101, Issue 11, Page 2799-2811, November 2026.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source