Results 91 to 100 of about 3,873 (265)
Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes
British Journal of Haematology, EarlyView.Summary We assessed the pregnancy outcomes of patients with sickle cell crises. We carried out a retrospective study of 2 698 556 pregnancies in Quebec, Canada between 1989 and 2022. The primary exposure was sickle cell anaemia with crisis during or outside of pregnancy. Outcomes included severe maternal morbidity and other pregnancy complications.
Nathalie Auger +8 more
wiley +1 more source
Prevalence of hemoglobinopathies in school children: the importance of using confirmatory methods
Brazilian Journal of Pharmaceutical Sciences, 2015 The hemoglobinopathies are included among the most common genetic diseases in the world. In Brazil, hemoglobinopathies are related to the diversity of racial backgrounds and the degree of interbreeding.
Cristiane Fernandes de Freitas Tavares +2 more
doaj +1 more source
Cell Proliferation, EarlyView.The use of FG‐4592 in the process of myeloablation can promote haematopoietic cell apoptosis for more effective myeloablation, maintain the number of RBC and may create a pluripotent microenvironment suitable for donor cells, so as to enable more effective haematopoietic reconstruction of donor cells in vivo.
Guanheng Yang +8 more
wiley +1 more source
Deletional alpha thalassemias in Cukurova
, 1999 Purpose: The production of the ?-chains are reduced or abolished in ?-thalassemia. The ?-thalassemia-2 and ?-thalassemia-1 are common in Southeast and Mediterranean countries.
Yuregir G.T. +3 more
core +1 more source
Gene Editing for Haemophilia—The Next Frontier
Haemophilia, EarlyView.ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti +3 more
wiley +1 more source
Silent thalassemias: genotypes and phenotypes
Haematologica, 1997 BACKGROUND AND OBJECTIVE: Current application of molecular biology techniques to the study of the DNA of globin genes has confirmed the existence of silent alpha and beta thalassemias; which had already been reported on the basis of red blood cell ...
I Bianco +9 more
doaj
Thalassemias and related disorders: quantitative disorders of hemoglobin synthesis.
, 2009 A very comprehensive approach to the thalassemias, from the molecular to the clinical aspects. A special attention is dedicated to all the possible complications, to their prevention and treatment.
BORGNA, Caterina, GALANELLO R.
core
Haemophilia, EarlyView.ABSTRACT Introduction Patients with inherited bleeding and haemoglobin disorders face barriers to accessing timely dental care, increasing the risk of untreated oral disease and complications related to invasive procedures. Aim To evaluate the agreement between smartphone‐based asynchronous teledentistry and face‐to‐face examination for oral conditions,
Victor Cordeiro da Silva +7 more
wiley +1 more source
Therapeutic Relevance of Inducing Autophagy in β-Thalassemia
CellsThe β-thalassemias are inherited genetic disorders affecting the hematopoietic system. In β-thalassemias, more than 350 mutations of the adult β-globin gene cause the low or absent production of adult hemoglobin (HbA).
Roberto Gambari, Alessia Finotti
doaj +1 more source
Hemodialysis International, EarlyView.ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha +6 more
wiley +1 more source