Results 111 to 120 of about 4,160 (239)

CRISPR Technology: From Bench to Bedside Applications

MedComm, Volume 7, Issue 11, November 2026.
This review systematically dissects the molecular mechanisms, advantages, and limitations of core CRISPR editing platforms including base editors (Panel A) and prime editing (Panel B); summarizes pivotal clinical data across hemoglobinopathies, CAR‐T immunotherapy, muscular dystrophy, cystic fibrosis, cardiometabolic diseases, and rare monogenic ...
Xinzhi Ma, Lingyu Li, Yingli Sun
wiley   +1 more source

125 - Rheumatic Manifestations of Hemoglobinopathies

Hemoglobinopathies are inherited diseases caused by mutations in globin genes. Thalassemias are inherited defects in globin chain synthesis resulting in hypochromia and microcytosis.
Lozada, Carlos J., Carpintero, Maria F.   +1 more
core   +1 more source

Intratumoral and Peritumoral Functional Connectivity Reveals Network‐Level Signatures of Glioma

MedComm, Volume 7, Issue 11, November 2026.
Using resting‐state fMRI in 306 glioma patients, this study maps individualized intra‐ and peritumoral functional networks. Novel metrics (RIFR, RPTR) quantify tumor‐related network remodeling, correlating with pathology, structure, cognition, and survival. A prognostic model incorporating these network features achieves an AUC of 0.90.
Hongbo Bao, Yan Bai, Jie Hu, Wencai Ding, Jiacheng Lai, Andrew Zalesky, Ye Ella Tian, Yanmei Tie, Janet Mei, Shengyu Fang, Xing Fan, Licia P. Luna, Craig K. Jones, Jianxun Ren, Weigang Cui, Jiadong Yan, Zeya Yan, Zihan Wang, Renwu Zhang, Zhonghua Lv, Yihang Jiao, Tao Jiang, Peng Liang, Haris I. Sair, Yinyan Wang   +24 more
wiley   +1 more source

Genotypic‐Phenotypic Correlations in Non‐HbE β‐Thalassemia Intermedia: A Geographic Systematic Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 11, November 2026.
β‐Thalassemia intermedia exhibits distinct region‐specific molecular patterns shaped by three interacting genetic axes: β‐globin mutation severity, HbF‐inducing modifiers, and α‐globin gene dosage. Mediterranean populations are predominantly mutation‐driven, Middle Eastern populations rely on HbF compensation, and Asian populations are governed by ...
Kavindya Fernando, Shiromi Perera, Anuja Premawardhena   +2 more
wiley   +1 more source

The role of iron in normal and impaired testicular function

Andrology, Volume 14, Issue 8, Page 2373-2387, November 2026.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Carrying a crisis: The risk of a painful sickle cell crisis during pregnancy

British Journal of Haematology, Volume 209, Issue 5, Page 2387-2388, November 2026.
Commentary on: Auger et al. Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes. Br J Haematol. 2026;209:2264–2272.
Bart J. Biemond
wiley   +1 more source

In vitro inhibition of BCL11A gene expression by RNAi for the Treatment of ?-Thalassemia

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Thalassemias are general genetic disorders in the Indian subcontinent. Thalassemia is a kind of genetic disorder of the blood that is passed from one generation to the other, exemplified by reduced or absent amounts of hemoglobin.
Vikas Urkude, Amit Mishra, Mahavir Yadav, Archana Tiwari   +3 more
doaj  

Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes

British Journal of Haematology, Volume 209, Issue 5, Page 2264-2272, November 2026.
Summary We assessed the pregnancy outcomes of patients with sickle cell crises. We carried out a retrospective study of 2 698 556 pregnancies in Quebec, Canada between 1989 and 2022. The primary exposure was sickle cell anaemia with crisis during or outside of pregnancy. Outcomes included severe maternal morbidity and other pregnancy complications.
Nathalie Auger, Émilia Mailhot‐Diaferia, Gabriel Côté‐Corriveau, Gilles Paradis, Antoine Lewin, Aimina Ayoub, Anne‐Marie Parrot, Ashley Park, Brian Potter   +8 more
wiley   +1 more source

Development of HEK293T cell reference materials for β-thalassemia genetic testing using prime editing

Türk Biyokimya Dergisi
β-Thalassemias, caused by mutations in HBB, are hereditary blood disorders that impose a significant global health burden. Detecting these mutations through accurate genetic analysis is essential. This study aimed to create a panel of cell type reference
Ren Baoyan, Lu Jiahao, Tan Weihe, Lin Kangfeng, Xu Jingping, Zheng Yu, Xing Xingan, Zhou Qiaomiao   +7 more
doaj   +1 more source

Hemoglobin—A Review of Structure, Mechanisms and Analysis in the Clinical Diagnostic Laboratory

LabMed
This review focuses on the analysis of hemoglobin in the clinical laboratory with an emphasis on the structure–function relationships of hemoglobin and the various methodologies used for its measurement.
Neil S. Harris, Paul Boothe, Hanna Mbatia, William E. Winter, Maximo J. Marin   +4 more
doaj   +1 more source