Results 111 to 120 of about 3,873 (265)

In vitro inhibition of BCL11A gene expression by RNAi for the Treatment of ?-Thalassemia

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Thalassemias are general genetic disorders in the Indian subcontinent. Thalassemia is a kind of genetic disorder of the blood that is passed from one generation to the other, exemplified by reduced or absent amounts of hemoglobin.
Vikas Urkude, Amit Mishra, Mahavir Yadav, Archana Tiwari   +3 more
doaj  

Development of HEK293T cell reference materials for β-thalassemia genetic testing using prime editing

Türk Biyokimya Dergisi
β-Thalassemias, caused by mutations in HBB, are hereditary blood disorders that impose a significant global health burden. Detecting these mutations through accurate genetic analysis is essential. This study aimed to create a panel of cell type reference
Ren Baoyan, Lu Jiahao, Tan Weihe, Lin Kangfeng, Xu Jingping, Zheng Yu, Xing Xingan, Zhou Qiaomiao   +7 more
doaj   +1 more source

Hemoglobin—A Review of Structure, Mechanisms and Analysis in the Clinical Diagnostic Laboratory

LabMed
This review focuses on the analysis of hemoglobin in the clinical laboratory with an emphasis on the structure–function relationships of hemoglobin and the various methodologies used for its measurement.
Neil S. Harris, Paul Boothe, Hanna Mbatia, William E. Winter, Maximo J. Marin   +4 more
doaj   +1 more source

The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Iron overload disrupts bone homeostasis by suppressing osteoblast survival and mineralization, while promoting osteoclastogenesis. As a programmed cell death driven by iron‐dependent lipid peroxidation and glutathione peroxidase 4 (GPX4) downregulation. This study investigated the role of ferroptosis in bone cells under iron overload. Exposure
Supagarn Sooksawanwit, Kornkamon Lertsuwan, Natnicha Tannop, Ploypapus Lapatkeattisukul, Thanayuth Jenpichitkulchai, Nittiyaporn Sotapong, Jarinthorn Teerapornpuntakit, Tueanjai Khunluck, Siriwan Punvilai, Narattaphol Charoenphandhu   +9 more
wiley   +1 more source

Hb SKMC and an unprecedented γδβ-thalassemia: first report from Iraq

Hematology
Background Thalassemias are genetic disorders of globin chain synthesis. In Iraq, β-thalassemia is more prevalent than α-thalassemia. This study identifies two unpredicted globin gene mutations, a rare α-globin gene mutation (Hb SKMC) and a novel γδβ ...
Rawand P. Shamoon, Amir Charkaneh, Elena Di Pierro, Milena Irrera, Cristina Curcio, Ahmed Yassin, Rozhgar A. Khailany   +6 more
doaj   +1 more source

Evaluating Reproductive Health Recommendations in CPGs for Sickle Cell Disease: An Umbrella Review

Clinical and Public Health Guidelines, Volume 3, Issue 4, October 2026.
ABSTRACT Background Individuals with sickle cell disease or trait (SCD/T) face significant reproductive health risks, highlighting the need to assess the best available evidence on their reproductive health needs. Objectives To assess the quality of SCD/T clinical practice guidelines and evaluate the key characteristics and quality of their ...
Lisa R. Roberts, Marc Julmisse, Safiye Sahin, Jan M. Nick, Shanalee Tamares   +4 more
wiley   +1 more source

Clinical Significance of Diagnostic Images in Beta-Thalassemia

Вестник рентгенологии и радиологии
Thalassemias represent a heterogeneous group of autosomal recessive disorders resulting from reduced synthesis of alpha or beta hemoglobin chains causing structural abnormalities in red blood cells with their premature destruction accompanied by ...
O. V. Teplyakova, E. Z. Eidlina, O. G. Tsvetkova, A. А. Zhilyakov   +3 more
doaj   +1 more source

The Effect of N‐Acetyl Cysteine on Serum Lipid Profile and Heavy Metals in Women With Endometriosis Undergoing ICSI: A Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Endometriosis is associated with oxidative stress and heavy metal accumulation. This study evaluated whether N‐acetylcysteine (NAC) reduces serum heavy metals and improves lipid profiles in women with endometriosis undergoing fertility treatment.
Fatemeh Khorasani, Parvaneh Mirabi, Sedighe Esmaeilzadeh   +2 more
wiley   +1 more source

Spectrum of thalassemias and hemoglobinopathies in West Bengal: A study of 90,210 cases by cation exchange high-performance liquid chromatography method over a period of 8 years

, 2014
Background: Thalassemias and hemoglobinopathies are highly prevalent in India. Identification of these disorders is important for epidemiologic purposes and for prevention of thalassemia major and clinically severe hemoglobinopathies. Objectives: The aim
Nikhilesh Das, Senjuti Dasgupta, Saikat Mondal, Santosh Kumar Mondal   +3 more
core   +1 more source

Multicentric Asynchronous Endocrine Mucin‐Producing Sweat Gland Carcinoma and Mucinous Carcinoma of the Skin

Journal of Cutaneous Pathology, Volume 53, Issue 10, Page 901-906, October 2026.
ABSTRACT Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is an adnexal neoplasm which typically occurs on periorbital skin and demonstrates overlapping histopathologic features with primary mucinous carcinoma of the skin (MCS). Herein, we report a patient who developed five distinct lesions of EMPSGC and MCS over an eight‐year period, some of ...
Ikuko Hirai, Joseph F. Sobanko, Tara C. Mitchell, Jacquelyn Roth, Rosalie Elenitsas, Emily Y. Chu   +5 more
wiley   +1 more source