Results 131 to 140 of about 2,702 (213)

Assessment and Benchmarking of Model Informed Approaches in Drug Development for Hemoglobinopathies: A Review of Scientific Advices From January 2000 to December 2024

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Despite the fact that modeling and simulation are now recognized as promising innovative methodologies, their use in the context of development of drugs for sickle cell disease and Thalassemia has not yet been reviewed. Considering the challenges of conducting clinical trials for hemoglobinopathies, our work aims at exploring the current ...
Grace Shalom Govere   +2 more
wiley   +1 more source

Sickle cell β-thalassemia diagnosed at age 40: a case report. [PDF]

open access: yesAnn Hematol
Nikolaidis CG   +3 more
europepmc   +1 more source

Twin Pregnancies—Emergency Cerclage in the Second Trimester and Delivery of Second Twins 110 and 123 Days Later

open access: yesReproductive, Female and Child Health, Volume 5, Issue 1, March 2026.
ABSTRACT Background: Since the 1980s, the global twinning rate has risen to about 1.6 million twin pairs annually due to the widespread use of IVF. Twin pregnancies carry a higher risk of complications compared to singleton pregnancies, with cervical insufficiency being a significant concern that can lead to preterm birth and adverse perinatal outcomes.
Iakovos Soussis   +5 more
wiley   +1 more source

Assessment of β-Thalassemia Trait Occurrence in an Outpatient Sample from Southern Chile: A Retrospective Study. [PDF]

open access: yesDiagnostics (Basel)
Balcázar-Villarroel M   +9 more
europepmc   +1 more source

The Ticking Clock: Differential Time‐Dependent Deterioration Between Washed and Thawed Sperm

open access: yesAndrology, Volume 14, Issue 3, Page 923-932, March 2026.
ABSTRACT Background Cryopreservation is widely used in assisted reproductive technologies. While fresh sperm undergoes gradual time‐dependent deterioration, it remains unclear whether thawed sperm exhibits a more accelerated decline. Objectives To directly compare the rate of deterioration in sperm motility, vitality, and DNA fragmentation between ...
Adiel Kahana   +6 more
wiley   +1 more source

Burden of hemoglobinopathies and hemolytic anemias in the World Health Organization African region, 2000-2021: Findings from the Global Burden of Disease 2021 study. [PDF]

open access: yesPLOS Glob Public Health
GBD 2021 Hemoglobinopathies and Hemolytic Anemias Collaborators   +32 more
europepmc   +1 more source

Medical haematology: Repositioning haematology at the centre of medicine

open access: yesBritish Journal of Haematology, Volume 208, Issue 3, Page 845-854, March 2026.
The complementary domains of Medical Haematology and Haemato‐Oncology share a biological framework. The left panel depicts red cells, platelets, coagulation, thrombosis and innate immunity, while the right panel shows lymphoid and myeloid malignancies.
Cheng Hock Toh, Imelda Bates, Sue Pavord
wiley   +1 more source

Stroke burden and functional impacts in adults with sickle cell disease

open access: yesBritish Journal of Haematology, Volume 208, Issue 3, Page 1063-1073, March 2026.
Stroke was identified in 4.6% of 454 adults with sickle cell disease. Stroke occurred not only across HbSS/Sβ0 phenotypes but also HbSC/Sβ+ as well, challenging traditional assumptions. Stroke was associated with long‐term functional impairment, including cognitive deficits and higher disability scores.
Jonathan St‐Onge   +12 more
wiley   +1 more source

Advancing Hematopoietic Stem Cell Transplantation (HSCT) in Africa: A Pathway to Curing Hematological Disorders. [PDF]

open access: yesHealth Sci Rep
Ogunniyi TJ   +9 more
europepmc   +1 more source

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